ArticleFrontiers in genetics2012
More epigenetic hits than meets the eye: microRNAs and genes associated with the tumorigenesis of retinoblastoma.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Comprehensive investigation of long non-coding RNA HOTAIR polymorphisms and cancer risk: a current meta-analysis encompassing 96,458 participants.Scientific reports · 2024Pooled it
- Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma.Current issues in molecular biology · 2024Review
- Second hit impels oncogenesis of retinoblastoma in patient-induced pluripotent stem cell-derived retinal organoids: direct evidence for Knudson's theory.PNAS nexus · 2022Article
- Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma.Frontiers in cell and developmental biology · 2022Article
- Long Non-coding RNA FEZF1-AS1 Promotes Growth and Reduces Apoptosis Through Regulation of miR-363-3p/PAX6 Axis in Retinoblastoma.Biochemical genetics · 2021Article
- Biomarkers in retinoblastoma.International journal of ophthalmology · 2020Review
- CircRNA Is a Rising Star in Researches of Ocular Diseases.Frontiers in cell and developmental biology · 2020Review
- Expression profiles and prognostic value of miRNAs in retinoblastoma.Journal of cancer research and clinical oncology · 2019Review
- A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma.Cancer biomarkers : section A of Disease markers · 2017Article
- Biomarkers of genome instability and cancer epigenetics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy.Experimental and therapeutic medicine · 2016Article
- A Functional Polymorphism (rs937283) in the MDM2 Promoter Region is Associated with Poor Prognosis of Retinoblastoma in Chinese Han Population.Scientific reports · 2016Article
- Pathogenic Network Analysis Predicts Candidate Genes for Cervical Cancer.Computational and mathematical methods in medicine · 2016Article
- Orchestrating epigenetic roles targeting ocular tumors.OncoTargets and therapy · 2016Review
- Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.Scientific reports · 2015Article
- Down-Regulation of miR-146a Expression Induces Allergic Conjunctivitis in Mice by Increasing TSLP Level.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- miRNA signature identification of retinoblastoma and the correlations between differentially expressed miRNAs during retinoblastoma progression.Molecular vision · 2015Article
- Suppressor of Zeste 12 homolog RNA interference inhibits retinoblastoma cell invasion.Oncology letters · 2014Article
- Characterizing the Retinoblastoma 1 locus: putative elements for Rb1 regulation by in silico analysis.Frontiers in genetics · 2014Article
- Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal cancer.Digestive diseases and sciences · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoblastoma (RB), a childhood neoplasia of the retinoblasts, can occur unilaterally or bilaterally, with one or multiple foci per eye. RB is associated with somatic loss of function of both alleles of the tumor suppressor gene RB1. Hereditary forms emerge due to germline loss of function mutations in RB1 alleles. RB has long been the prototypic "model" cancer ever since Knudson's "two-hit" hypothesis. However, a simple two-hit model for RB is challenged by an increasing number of studies documenting additional hits that contribute to RB development. Here we review the genetics and epigenetics of RB with a focus on the role of small non-coding RNAs (microRNAs) and on novel findings indicating the relevance of DNA methylation in the development and prognosis of this neoplasia. Studies point to an elaborated landscape of genetic and epigenetic complexity, in which a number of events and pahtways play crucial roles in the origin and prognosis of RB. These include roles for microRNAs, inprinted loci, and parent-of-origin contributions to RB1 regulation and RB progression. This complexity is also manifested in the structure of the RB1 locus itself: it includes numerous repetitive DNA segments and retrotransposon insertion elements, some of which are actively transcribed from the RB1 locus. Altogether, we conclude that RB1 loss of function represents the tip of an iceberg of events that determine RB development, progression, severity, and disease risk. Comprehensive assessment of personalized RB risk will require genetic and epigenetic evaluations beyond RB1 protein coding sequences.
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