ArticleFrontiers in physiology2012
The arterial baroreflex resets with orthostasis.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Orthostatic-dependent cardiopulmonary responses among trained females during intensity matched resistance exercises in a pilot randomized crossover study.Scientific reports · 2025Trial
- Haemodynamic determinants of supine hypertension in patients with classical orthostatic hypotension.Journal of hypertension · 2026Article
- Differential frequency-dependent reflex summation of the aortic baroreceptor afferent input.Pflugers Archiv : European journal of physiology · 2023Article
- Cardiovascular response to postural perturbations of different intensities in healthy young adults.Physiological reports · 2022Article
- Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Cardiovascular fingolimod effects on rapid baroreceptor unloading are counterbalanced by baroreflex resetting.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Sex differences in the ventilatory and cardiovascular response to supine and tilted metaboreflex activation.Physiological reports · 2019Article
- Cardiovascular responses to leg muscle loading during head-down tilt at rest and after dynamic exercises.Scientific reports · 2019Article
- Assessment of Baroreflex Sensitivity Using Time-Frequency Analysis during Postural Change and Hypercapnia.Computational and mathematical methods in medicine · 2019Article
- Higher blood pressure and lower cardiac vagal activity in obese young individuals in supine and seated position.Journal of clinical and translational research · 2018Article
- Baroreflex function, haemodynamic responses to an orthostatic challenge, and falls in haemodialysis patients.PloS one · 2018Article
- Modeling the effect of tilting, passive leg exercise, and functional electrical stimulation on the human cardiovascular system.Medical & biological engineering & computing · 2017Article
- Distinctive Steady-State Heart Rate and Blood Pressure Responses to Passive Robotic Leg Exercise during Head-Up Tilt: A Pilot Study in Neurological Patients.Frontiers in physiology · 2017Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- Distinctive Steady-State Heart Rate and Blood Pressure Responses to Passive Robotic Leg Exercise and Functional Electrical Stimulation during Head-Up Tilt.Frontiers in physiology · 2016Article
- Self-Organization of Blood Pressure Regulation: Clinical Evidence.Frontiers in physiology · 2016Article
- Self-Organization of Blood Pressure Regulation: Experimental Evidence.Frontiers in physiology · 2016Article
- Arterial blood pressure response to head-up tilt test and orthostatic tolerance in nurses.Environmental health and preventive medicine · 2015Article
- Spontaneous fluctuation indices of the cardiovagal baroreflex accurately measure the baroreflex sensitivity at the operating point during upright tilt.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Neural control of the circulation during exercise in health and disease.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The arterial baroreflexes, located in the carotid sinus and along the arch of the aorta, are essential for the rapid short term autonomic regulation of blood pressure. In the past, they were believed to be inactivated during exercise because blood pressure, heart rate, and sympathetic activity were radically changed from their resting functional relationships with blood pressure. However, it was discovered that all relationships between carotid sinus pressure and either HR or sympathetic vasoconstriction maintained their curvilinear sigmoidal shape but were reset or shifted so as to best defend BP during exercise. To determine whether resetting also occurs during orthostasis, we examined the arterial baroreflexes measured supine and upright tilt. We studied the relationships between systolic BP and HR (the cardiovagal baroreflex), mean BP, and ventilation (the ventilatory baroreflex) and diastolic BP and sympathetic nerve activity (the sympathetic baroreflex). We accomplished these measurements by using the modified Oxford method in which BP was rapidly varied with bolus injections of sodium nitroprusside followed 1 min later by bolus injections of phenylephrine. Both the cardiovagal and ventilatory baroreflexes were "reset" with no change in gain or response range. In contrast, the sympathetic baroreflex was augmented as well as shifted causing an increase in peripheral resistance that improved the subjects' defense against hypotension. This contrasts with findings during exercise in which peripheral resistance in active skeletal muscle is not increased. This difference is likely selective for exercising muscle and may represent the actions of functional sympatholysis by which exercise metabolites interfere with adrenergic vasoconstriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.