ArticleCancer prevention research (Philadelphia, Pa.)2013
Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer.
Article in Cancer prevention research (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Pancreatic Acinar Cell Carcinoma: A Rare Pancreatic Malignancy with Distinct Biology and Emerging Therapeutic Opportunities.Cancers · 2026Review
- Reduced Progenitor Function and Altered Immune Landscape Contribute to Field Cancerization of Lung Adenocarcinoma.American journal of respiratory and critical care medicine · 2023Article
- A computational model for the cancer field effect.Frontiers in artificial intelligence · 2023Article
- Successful Use of Photodynamic Therapy in a Patient with Squamous Cell Carcinoma of the Lung and Diffuse Endobronchial Lesions.Journal of community hospital internal medicine perspectives · 2022Article
- RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.International journal of biological sciences · 2021Article
- Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis.OncoTargets and therapy · 2020Review
- Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis.Journal of thoracic disease · 2019Review
- Predicting progression ofJournal of thoracic disease · 2019Article
- The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Review
- An evolutionary perspective on field cancerization.Nature reviews. Cancer · 2018Review
- LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells.Oncogene · 2016Article
- Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Article
- LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells.Scientific reports · 2015Article
- Molecular characterization of the peripheral airway field of cancerization in lung adenocarcinoma.PloS one · 2015Article
- Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and Insights into the Molecular Pathology.Frontiers in medicine · 2015Review
- Matrix metalloproteinase-19 promotes metastatic behavior in vitro and is associated with increased mortality in non-small cell lung cancer.American journal of respiratory and critical care medicine · 2014Article
- APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation.Virchows Archiv : an international journal of pathology · 2014Article
- Update in lung cancer and mesothelioma 2012.American journal of respiratory and critical care medicine · 2013Review
Corrections and comments
- Comment on
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The "field of cancerization" refers to histologically normal-appearing tissue adjacent to neoplastic tissue that displays molecular abnormalities, some of which are the same as those of the tumor. Improving our understanding of these molecular events is likely to increase our understanding of carcinogenesis. Kadara and colleagues attempt to characterize the molecular events occurring temporally and spatially within the field of cancerization of patients with early-stage non-small cell lung cancer (NSCLC) following definitive surgery. They followed patients with bronchoscopies annually after tumor resection and extracted RNA from the serial brushings from different endobronchial sites. They then conducted microarray analysis to identify gene expression differences over time and in different sites in the airway. Candidate genes were found that may have biologic relevance to the field of cancerization. For example, expression of phosphorylated AKT and ERK1/2 was found to increase in the airway epithelium with time. Although there are limitations in the study design, this investigation demonstrates the utility of identifying molecular changes in histologically normal airway epithelium in lung cancer. In addition to increasing our understanding of lung cancer biology, studying the field of cancerization has the potential to identify biomarkers from samples obtained in a minimally invasive manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.