ArticleMicrobiologyOpen2012
A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli.
Article in MicrobiologyOpen, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Molecular basis of antibiotic sensing by the TetR family regulator CecR - a structural perspective.The FEBS journal · 2026Article
- Effects of multiple cell regulators on curli gene expression inJournal of bacteriology · 2025Article
- EefR mutations drive sanguinarine resistance by activating cryptic multidrug efflux pumps in AcrB-NullVirulence · 2025Article
- RcsB and H-NS Both Contribute to the Repression the Expression of theMicroorganisms · 2025Article
- MSMEG_5850, a global TetR family member supports Mycobacterium smegmatis to survive environmental stress.Folia microbiologica · 2025Article
- Regulatory Role of GgaR (YegW) for Glycogen Accumulation inMicroorganisms · 2024Article
- CsgI (YccT) Is a Novel Inhibitor of Curli Fimbriae Formation inInternational journal of molecular sciences · 2023Article
- The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA.Communications biology · 2023Article
- Transcription Factor SrsR (YgfI) Is a Novel Regulator for the Stress-Response Genes in Stationary Phase inInternational journal of molecular sciences · 2022Article
- RegulonDB 11.0: Comprehensive high-throughput datasets on transcriptional regulation inMicrobial genomics · 2022Article
- Trimethylamine N-Oxide Reduces the Susceptibility ofFrontiers in microbiology · 2022Article
- Single-Target Regulators Constitute the Minority Group of Transcription Factors inFrontiers in microbiology · 2021Article
- Article
- TetR-family transcription factors in Gram-negative bacteria: conservation, variation and implications for efflux-mediated antimicrobial resistance.BMC genomics · 2019Article
- A unified resource for transcriptional regulation in Escherichia coli K-12 incorporating high-throughput-generated binding data into RegulonDB version 10.0.BMC biology · 2018Article
- The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.Nucleic acids research · 2017Article
- Transcription profile of Escherichia coli: genomic SELEX search for regulatory targets of transcription factors.Nucleic acids research · 2016Article
- Intracellular concentrations of 65 species of transcription factors with known regulatory functions in Escherichia coli.Journal of bacteriology · 2014Article
- Curli biogenesis: order out of disorder.Biochimica et biophysica acta · 2014Review
- Identification of the set of genes, including nonannotated morA, under the direct control of ModE in Escherichia coli.Journal of bacteriology · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FixJ/LuxR family transcription factor CsgD is a master regulator of biofilm formation in Escherichia coli. Previously, we identified more than 10 transcription factors that participate in regulation of the csgD promoter. After genomic SELEX screening of regulation targets, an uncharacterized TetR-type transcription factor YbjK was found to be involved in regulation of the csgD promoter. In addition, a number of stress-response genes were found to be under the direct control of YbjK. Taken together, we propose to rename it to RcdA (regulator of csgD). One unique feature of RcdA is its mode of DNA binding. Gel shift, DNase-I footprinting, and atomic force microscopic (AFM) analyses indicated that RcdA is a DNA-binding protein with a high level of cooperativity, with which it covers the entire surface of probe DNA through protein-protein interaction and moreover it induces the formation of aggregates of DNA-RcdA complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.