ReviewJournal of neural transmission (Vienna, Austria : 1996)2013
Genetics of impulse control disorders in Parkinson's disease.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association between 5-HTTLPR polymorphism and Parkinson's disease: a meta analysis.Molecular biology reports · 2014Pooled it
- Serotonergic cortico-limbic and executive network dysfunction in Parkinson's disease impulse control disorders: a PET-fMRI study.NPJ Parkinson's disease · 2026Article
- Impulse control disorders in Parkinson's disease: What's new?Journal of neurology · 2025Review
- Neuro-functional correlates of personality dimensions in Parkinson's disease.Frontiers in pharmacology · 2025Article
- APOE contributes to longitudinal impulse control disorders progression in Parkinson's disease.BMC psychiatry · 2024Article
- Roles of the Functional Interaction between Brain Cholinergic and Dopaminergic Systems in the Pathogenesis and Treatment of Schizophrenia and Parkinson's Disease.International journal of molecular sciences · 2021Review
- Polymorphisms of Dopamine Receptor Genes and Parkinson's Disease: Clinical Relevance and Future Perspectives.International journal of molecular sciences · 2021Review
- Dopamine genetic risk score predicts impulse control behaviors in Parkinson's disease.Clinical parkinsonism & related disorders · 2021Article
- Impulse Control Disorders in REM Sleep Behavior Disorder.Current treatment options in neurology · 2019Review
- Neurobiology and clinical features of impulse control failure in Parkinson's disease.Neurological research and practice · 2019Review
- Sleep in Parkinson's Disease with Impulse Control Disorder.Current neurology and neuroscience reports · 2018Review
- Impulse control disorders in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease.Frontiers in neurology · 2018Article
- Impulse control behaviors and subthalamic deep brain stimulation in Parkinson disease.Journal of neurology · 2017Article
- Clinical-genetic model predicts incident impulse control disorders in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2016Article
- Trait Impulsivity and Anhedonia: Two Gateways for the Development of Impulse Control Disorders in Parkinson's Disease?Frontiers in psychiatry · 2016Article
- Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2015Review
- Impact of Impulse Control Disorders on Sleep-Wake Regulation in Parkinson's Disease.Parkinson's disease · 2015Review
- Developmental imaging genetics: linking dopamine function to adolescent behavior.Brain and cognition · 2014Review
- Impulsive and compulsive behaviors in Parkinson's disease.Annual review of clinical psychology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impulse control disorders (ICD) have been recognised in Parkinson's disease (PD) as adverse effects of dopamine replacement therapy, particularly with dopamine agonists. Although virtually all PD patients are treated with dopaminergic drugs, only a minority will develop hyperdopaminergic states, suggesting predisposing and/or protecting factors. The age at onset, the sex and the dose or type of dopaminergic drugs have been identified as clinical predictive factors. Recent genetic studies have investigated associations between ICD and polymorphisms of genes involved in the dopamine metabolism pathway (COMT, DAT), dopamine receptors (DRD1, DRD2, DRD3, DRD4), serotonin receptors and its transporter (HTR2A, 5HTT), and glutamate receptors (GRIN2B). Although validation in larger and independent cohorts is needed, the results from these studies give us some insights into the pathophysiology of hyperdopaminergic states and may be useful, at term, in personalising antiparkinsonian treatment in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.