ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
APOE E4 Carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment - a randomized double-blind placebo-controlled trial.Human psychopharmacology · 2016Trial
- Interactions between physical exercise, associative memory, and genetic risk for Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Evidence of emerging BBB changes in mid-age apolipoprotein E epsilon-4 carriers.Brain and behavior · 2022Article
- APOE genotype influences P3b amplitude and response to smoking abstinence in young adults.Psychopharmacology · 2021Article
- Cognitive performance effects of nicotine and industry affiliation: a systematic review.Substance abuse : research and treatment · 2020Article
- Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress.Journal of Alzheimer's disease : JAD · 2019Review
- Using event-related fMRI to examine sustained attention processes and effects of APOE ε4 in young adults.PloS one · 2018Article
- APOE ε4 genotype predicts memory for everyday activities.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2015Article
- Cognitive and neural signatures of the APOE E4 allele in mid-aged adults.Neurobiology of aging · 2014Article
- The potential applications of Apolipoprotein E in personalized medicine.Frontiers in aging neuroscience · 2014Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
There is evidence to suggest that the APOE ɛ4 allele (which confers an increased risk of developing dementia) might be associated with cognitive advantages earlier in life. Further, nicotine might selectively benefit ɛ4 carriers. We used fMRI to explore performance on a prospective memory (PM) task in young adults (age 18-30) with and without nicotine using a within-subjects design. Participants performed an ongoing task while retaining a PM instruction to respond to specific stimuli embedded in the task. Nicotine effects varied according to APOE status. Reaction times to the PM cue were improved under nicotine in ɛ4 carriers, but not in ɛ3 carriers. In an event-related analysis, extrastriate responses to PM trials were enhanced by nicotine only in ɛ4 carriers. These differences in early visual processing may contribute to the behavioral findings. Activity in medial BA10 (previously implicated in PM) differentiated ɛ4 from ɛ3 carriers. One BA10 subregion showed greater deactivation in ɛ4 carriers during PM trials. Activity in other BA10 subregions was modulated by PM reaction time, pointing to region-specific effects within medial BA10. In addition, activity in right hippocampal formation was only seen in ɛ4 carriers receiving nicotine. These results demonstrate that cognitive enhancement by nicotine can selectively benefit APOE ɛ4 carriers, and point to genotype-specific differences in neural activity during PM. In addition, these results show that the role of medial BA10 in PM likely involves varying contributions from functionally specific subregions.
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