Evidence map›Paper›PMID 23232159›Full record

ReviewNeuroRehabilitation2012

Central sensitization as a component of post-deployment syndrome.

Jeffrey D Lewis, Eric M Wassermann, Wendy Chao, Amy E Ramage, Donald A Robin, Daniel J Clauw

Abstract readReview
In one paragraph

Review in NeuroRehabilitation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jeffrey D LewisNational Institute of Neurological Disorders and Stroke, Behavioral Neurology Unit, Bethesda, MD, USA.
Eric M Wassermann
Wendy Chao
Amy E Ramage
Donald A Robin
Daniel J Clauw
The University of Texas Health Science Center at San Antonio · USJoint Base San Antonio · USNational Institute of Neurological Disorders and Stroke · USUniformed Services University of the Health Sciences · USUniversity of Michigan–Ann Arbor · US

Funding

Electrophysiological Probes And Treatments In Neurobehavioral DisordersZIANS002977 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WASSERMANN, ERIC M · 2009 to 2025
$14.6M
Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

Many service members and veterans report chronic unexplained symptoms such as pain, fatigue and memory complaints, which have most recently been characterized as post-deployment syndrome (PDS). Chronic widespread pain is a component of this syndrome, producing significant disability and considerable health care costs. The similarity between the nature of these complaints and other medically unexplained illnesses such as fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome suggest that they may share a common mechanism. Here, we provide support for PDS as a consequence of pain and sensory amplification secondary to neuroplastic changes within the central nervous system, a phenomenon often termed central sensitization. We also discuss how factors such as stress and genetics may promote chronic widespread pain in veterans and service members who develop PDS.

Indexed as

Military PersonnelBrain InjuriesCentral Nervous System SensitizationChronic PainFatigueHumansSyndromeVeterans

Identifiers

PMID23232159
PMCPMC4880352
OpenAlexW1816402274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.