ArticleHereditary cancer in clinical practice2012
Familial gastric cancer: detection of a hereditary cause helps to understand its etiology.
Article in Hereditary cancer in clinical practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- The tumor necrosis factor-α-238 polymorphism and digestive system cancer risk: a meta-analysis.Clinical and experimental medicine · 2016Pooled it
- Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis.Journal of cancer research and clinical oncology · 2013Pooled it
- Familial Non-Hereditary Gastric Cancer: Diagnosis, Management, Molecular Characteristics and Future Perspective.Cancers · 2025Review
- Role of Soluble Cytokine Receptors in Gastric Cancer Development and Chemoresistance.International journal of molecular sciences · 2025Review
- USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration.Recent patents on anti-cancer drug discovery · 2025Article
- Review
- Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer.Frontiers in oncology · 2023Review
- Gastric cancer: An epigenetic view.World journal of gastrointestinal oncology · 2022Review
- Gastric cancer: a comprehensive review of current and future treatment strategies.Cancer metastasis reviews · 2020Review
- Long non-coding RNA GAS5 in human cancer.Oncology letters · 2020Review
- Gastric Cancer in Aktobe Region of Western Kazakhstan from 2009 to 2018: Incidence Rates, Trends, and Five-Year Survival.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- The role of genomic profiling in adolescents and young adults (AYAs) with advanced cancer participating in phase I clinical trials.European journal of cancer (Oxford, England : 1990) · 2018Article
- Article
- How to stomach an epigenetic insult: the gastric cancer epigenome.Nature reviews. Gastroenterology & hepatology · 2017Review
- Syndrome-Associated Tumors by Organ System.Journal of pediatric genetics · 2016Review
- Lauren classification and individualized chemotherapy in gastric cancer.Oncology letters · 2016Article
- Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells.Molecular medicine reports · 2016Article
- XPC Ala499Val and XPG Asp1104His polymorphisms and digestive system cancer risk: a meta-analysis based on model-free approach.International journal of clinical and experimental medicine · 2015Article
- Presymptomatic identification of CDH1 germline mutation in a healthy korean individual with family history of gastric cancer.Annals of laboratory medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Worldwide, gastric cancer is one of the most common forms of cancer, with a high morbidity and mortality. Several environmental factors predispose to the development of gastric cancer, such as Helicobacter pylori infection, diet and smoking. Familial clustering of gastric cancer is seen in 10% of cases, and approximately 3% of gastric cancer cases arise in the setting of hereditary diffuse gastric cancer (HDGC). In families with HDGC, gastric cancer presents at relatively young age. Germline mutations in the CDH1 gene are the major cause of HDGC and are identified in approximately 25-50% of families which fulfill strict criteria. Prophylactic gastrectomy is the only option to prevent gastric cancer in individuals with a CDH1 mutation. However, in the majority of families with multiple cases of gastric cancer no germline genetic abnormality can be identified and therefore preventive measures are not available, except for general lifestyle advice. Future research should focus on identifying new genetic predisposing factors for all types of familial gastric cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.