ArticleBMC pediatrics2012
Causes and risk factors for infant mortality in Nunavut, Canada 1999-2011.
Article in BMC pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding the experiences, perspectives and values of indigenous women around smoking cessation in pregnancy: systematic review and thematic synthesis of qualitative studies.International journal for equity in health · 2019Pooled it
- Increased missense mutation burden of Fatty Acid metabolism related genes in nunavik inuit population.PloS one · 2015Trial
- Methodology and recruitment for a randomised controlled trial to evaluate the safety of wahakura for infant bedsharing.BMC pediatrics · 2014Trial
- Inborn errors of immunity in Canadian First Nations and Nunavut Inuit Children: the tip of the iceberg.Paediatrics & child health · 2025Article
- Risk factors of under-five and infant mortality: An umbrella review of systematic reviews and meta-analyses.Journal of global health · 2024Review
- A mild phenotype associated withFrontiers in pediatrics · 2024Article
- Article
- The CPT1A Arctic variant: perspectives of community members and providers in two Alaska tribal health settings.Journal of community genetics · 2023Article
- Characterization of T Helper 1 and 2 Cytokine Profiles in Newborns of Mothers with COVID-19.Biomedicines · 2023Article
- Noninvasive ventilation of air transported infants with respiratory distress in the Canadian Arctic.Paediatrics & child health · 2022Article
- Complex Survival System Modeling for Risk Assessment of Infant Mortality Using a Parametric Approach.Computational and mathematical methods in medicine · 2022Article
- Neonatal hypoglycemia and the CPT1A P479L variant in term newborns: A retrospective cohort study of Inuit newborns from Kivalliq Nunavut.Paediatrics & child health · 2021Article
- Association of theFrontiers in pediatrics · 2021Article
- Factors affecting infant mortality in the general population: evidence from the 2016 Ethiopian demographic and health survey (EDHS); a multilevel analysis.BMC pregnancy and childbirth · 2020Article
- Exploring vulnerabilities to sepsis in Canada.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Article
- The p.P479L variant in CPT1A is associated with infectious disease in a BC First Nation.Paediatrics & child health · 2019Article
- Sudden infant death and social justice: A syndemics approach.Maternal & child nutrition · 2019Article
- Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle.Reviews in endocrine & metabolic disorders · 2018Review
- Response to Koeller et al.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Health effects of the CPT1A P479L variant: responsible public health policy.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
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7 authors.
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Abstract
backgroundThe northern territory Nunavut has Canada's largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed those for the rest of Canada. The infant mortality rate in Nunavut is 3 times the national average, and twice that of the neighbouring territory, the Northwest Territories. Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections.
methodsTo determine the causes and potential risk factors of infant mortality in Nunavut, we reviewed all infant deaths (<1 yr) documented by the Nunavut Chief Coroner's Office and the Nunavut Bureau of Statistics (n=117; 1999-2011). Rates were compared to published data for Canada.
resultsSudden death in infancy (SIDS/SUDI; 48%) and infection (21%) were the leading causes of infant death, with rates significantly higher than for Canada (2003-2007). Of SIDS/SUDI cases with information on sleep position (n=42) and bed-sharing (n=47), 29 (69%) were sleeping non-supine and 33 (70%) were bed-sharing. Of those bed-sharing, 23 (70%) had two or more additional risk factors present, usually non-supine sleep position. CPT1A P479L homozygosity, which has been previously associated with infant mortality in Alaska Native and British Columbia First Nations populations, was associated with unexpected infant death (SIDS/SUDI, infection) throughout Nunavut (OR:3.43, 95% CI:1.30-11.47).
conclusionUnexpected infant deaths comprise the majority of infant deaths in Nunavut. Although the CPT1A P479L variant was associated with unexpected infant death in Nunavut as a whole, the association was less apparent when population stratification was considered. Strategies to promote safe sleep practices and further understand other potential risk factors for infant mortality (P479L variant, respiratory illness) are underway with local partners.
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