ArticleStem cells and development2013
An adipoinductive role of inflammation in adipose tissue engineering: key factors in the early development of engineered soft tissues.
Article in Stem cells and development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Mechanical Force Regulates the Paracrine Function of ADSCs to Promote the Adipose-Regenerating Effects of AAM by Regulating Angiogenesis and the Inflammatory Response.Cell proliferation · 2025Article
- Decellularized Extracellular Matrix Scaffolds for Soft Tissue Augmentation: From Host-Scaffold Interactions to Bottlenecks in Clinical Translation.Biomaterials research · 2024Review
- Successful fat-only whole breast reconstruction using cultured mature adipocytes and conditioned medium containing MCP-1.Scientific reports · 2023Article
- Immune Cell Regulation of White Adipose Progenitor Cell Fate.Frontiers in endocrinology · 2022Review
- Experimental study of fat derived pellets promoting wound healing in rats.Bioengineered · 2021Article
- Review
- Increase of glandular epithelial cell clusters by an external volume expansion device promotes adipose tissue regeneration by recruiting macrophages.Bioscience reports · 2019Article
- A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis.Frontiers in bioengineering and biotechnology · 2018Article
- Adipose Tissue Formation Utilizing Fat Flap Distraction Technique.Scientific reports · 2017Article
- Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model.BioMed research international · 2017Article
- Adipose-Derived Stem Cell Delivery for Adipose Tissue Engineering: Current Status and Potential Applications in a Tissue Engineering Chamber Model.Stem cell reviews and reports · 2016Review
- Creation of a Large Adipose Tissue Construct in Humans Using a Tissue-engineering Chamber: A Step Forward in the Clinical Application of Soft Tissue Engineering.EBioMedicine · 2016Article
- Hydrogel-Based Engineering of Beige Adipose Tissue.Journal of materials chemistry. B · 2015Article
- Bone marrow derived cells facilitate urinary bladder regeneration by attenuating tissue inflammatory responses.Central European journal of urology · 2015Article
- Tissue engineering chamber promotes adipose tissue regeneration in adipose tissue engineering models through induced aseptic inflammation.Tissue engineering. Part C, Methods · 2014Article
- Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage.Development (Cambridge, England) · 2014Article
- Article
- Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber.International journal of nanomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering and cell implantation therapies are gaining popularity because of their potential to repair and regenerate tissues and organs. To investigate the role of inflammatory cytokines in new tissue development in engineered tissues, we have characterized the nature and timing of cell populations forming new adipose tissue in a mouse tissue engineering chamber (TEC) and characterized the gene and protein expression of cytokines in the newly developing tissues. EGFP-labeled bone marrow transplant mice and MacGreen mice were implanted with TEC for periods ranging from 0.5 days to 6 weeks. Tissues were collected at various time points and assessed for cytokine expression through ELISA and mRNA analysis or labeled for specific cell populations in the TEC. Macrophage-derived factors, such as monocyte chemotactic protein-1 (MCP-1), appear to induce adipogenesis by recruiting macrophages and bone marrow-derived precursor cells to the TEC at early time points, with a second wave of nonbone marrow-derived progenitors. Gene expression analysis suggests that TNFα, LCN-2, and Interleukin 1β are important in early stages of neo-adipogenesis. Increasing platelet-derived growth factor and vascular endothelial cell growth factor expression at early time points correlates with preadipocyte proliferation and induction of angiogenesis. This study provides new information about key elements that are involved in early development of new adipose tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.