ArticleAnnals of the New York Academy of Sciences2012
The diverse applications of RNA-seq for functional genomic studies in Aspergillus fumigatus.
Article in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Robust induction of interferon and interferon-stimulated gene expression by influenza B/Yamagata lineage virus infection of A549 cells.PloS one · 2020Article
- RNA-Seq Profile Reveals Th-1 and Th-17-Type of Immune Responses in Mice Infected Systemically with Aspergillus fumigatus.Mycopathologia · 2018Article
- A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus.Virulence · 2018Article
- Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia.BMC genomics · 2017Article
- Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.PLoS pathogens · 2015Article
- Transcriptome analysis of the filamentous fungus Aspergillus nidulans directed to the global identification of promoters.BMC genomics · 2013Article
- The function and evolution of the Aspergillus genome.Trends in microbiology · 2013Review
- The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus.PloS one · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
The deep sequencing of an mRNA population, RNA-seq, is a very successful application of next-generation sequencing technologies (NGSTs). RNA-seq takes advantage of two key NGST features: (1) samples can be mixtures of different DNA pieces, and (2) sequencing provides both qualitative and quantitative information about each DNA piece analyzed. We recently used RNA-seq to study the transcriptome of Aspergillus fumigatus, a deadly human fungal pathogen. Analysis of the RNA-seq data indicates that there are likely tens of unannotated and hundreds of novel genes in the A. fumigatus transcriptome, mostly encoding for small proteins. Inspection of transcriptome-wide variation between two isolates reveals thousands of single nucleotide polymorphisms. Finally, comparison of the transcriptome profiles of one isolate in two different growth conditions identified thousands of differentially expressed genes. These results demonstrate the utility and potential of RNA-seq for functional genomics studies in A. fumigatus and other fungal human pathogens.
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