ArticleScientific reports2012
Doublesex target genes in the red flour beetle, Tribolium castaneum.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Genomic Features Underlying the Origin of Sociality and the Diversification of Caste Systems in Termites.Molecular biology and evolution · 2025Article
- Doublesex and GATAβ4 synergistically regulate the sex-dimorphic expression of storage protein 1 in Bombyx mori.PLoS genetics · 2025Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- A Conserved Somatic Sex Determination Cascade Instructs Trait-Specific Sexual Dimorphism in Horned Dung Beetles.Evolution & development · 2025Article
- Transcriptome and Expression Analysis of Glycerol Biosynthesis-Related Genes inInternational journal of molecular sciences · 2024Article
- Candidate target genes of the male-specific expressed Doublesex in the termite Reticulitermes speratus.PloS one · 2024Article
- Theme and variation in the evolution of insect sex determination.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Review
- Insight into weevil biology from a reference quality genome of the boll weevil, Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae).G3 (Bethesda, Md.) · 2023Article
- Distinct developmental mechanisms influence sexual dimorphisms in the milkweed bugProceedings. Biological sciences · 2023Article
- The function and evolution of a genetic switch controlling sexually dimorphic eye differentiation in honeybees.Nature communications · 2023Article
- A chromosome-level assembly supports genome-wide investigation of the DMRT gene family in the golden mussel (Limnoperna fortunei).GigaScience · 2022Article
- CRISPR/Cas9-Mediated Mutagenesis of Sex-SpecificCells · 2022Article
- Evolutionary History of Sexual Differentiation Mechanism in Insects.Molecular biology and evolution · 2022Article
- CRISPR/Cas9 mediated sex-ratio distortion by sex specific gene editing inSaudi journal of biological sciences · 2022Article
- Effects of Functional Depletion ofInsects · 2021Article
- miRNA-1-3p is an early embryonic male sex-determining factor in the Oriental fruit fly Bactrocera dorsalis.Nature communications · 2020Article
- Ovarian Transcriptomic Analyses in the Urban Human Health Pest, the Western Black Widow Spider.Genes · 2020Article
- Hemimetabolous insects elucidate the origin of sexual development via alternative splicing.eLife · 2019Article
- Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus.Insect biochemistry and molecular biology · 2019Article
- Identification and Characterization of theInternational journal of molecular sciences · 2019Article
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2 authors.
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Abstract
Sex determination cascade in insects terminates with the production of sex-specific protein, Doublesex (Dsx). We identified the dsx homolog (Tcdsx) in Tribolium castaneum. The pre-mRNA of Tcdsx is sex-specifically spliced into three female (Tcdsxf1, Tcdsxf2 and Tcdsxf3) and one male-specific (Tcdsxm) isoforms. Cis-regulatory elements potentially involved in sex-specific splicing of the Tcdsx pre-mRNA were identified in the female-specific exon and the adjoining intronic sequences. All the three female-specific TcDsx proteins share common OD1 and OD2 domains and differ in their C-terminal sequences. Knockdown of Tcdsx resulted in a reduction in the oocyte development, egg production and hatching of eggs laid. Several genes, including those coding for Vitellogenins and Vitellogenin receptors were identified as targets of TcDsx. RNAi experiments showed an isoform-specific targeting of identified target genes by TcDsx as knockdown in the expression of Tcdsx isoforms individually or in combinations resulted in differential effects on the expression of target genes.
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