ArticleScientific reports2012
Multiple roles of the ER stress sensor IRE1 demonstrated by gene targeting in rice.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features.Frontiers in plant science · 2022Pooled it
- Transcriptome analysis coupled with virus induced gene silencing delineates the unfolded protein response of tomato.Molecular genetics and genomics : MGG · 2026Article
- Mining of genes and pathways associated with endoplasmic reticulum stress in Brassica campestris via RNA-Seq.Plant cell reports · 2026Article
- TaIRE1-mediated unconventional splicing of the TabZIP60 mRNA and the miR172 precursor regulates heat stress tolerance in wheat.Journal of integrative plant biology · 2025Article
- Comparative analysis of IRE1s in plants: insights into heat stress adaptation in Triticum aestivum.BMC plant biology · 2024Article
- Dynamics of ER stress-induced gene regulation in plants.Nature reviews. Genetics · 2024Review
- ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth.Plants (Basel, Switzerland) · 2022Review
- Targeted genome editing of plants and plant cells for biomanufacturing.Transgenic research · 2021Review
- Characterization of a new rice OsMADS1 null mutant generated by homologous recombination-mediated gene targeting.Planta · 2021Article
- AtIRE1C, an unconventional isoform of the UPR master regulator AtIRE1, is functionally associated with AtIRE1B in Arabidopsis gametogenesis.Plant direct · 2019Article
- Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis.Life science alliance · 2019Article
- ER-localized adenine nucleotide transporter ER-ANT1: an integrator of energy and stress signaling in rice.Plant molecular biology · 2016Article
- Progress of targeted genome modification approaches in higher plants.Plant cell reports · 2016Review
- Endoplasmic Reticulum Stress Signaling in Plant Immunity--At the Crossroad of Life and Death.International journal of molecular sciences · 2015Review
- Article
- The effect of the unfolded protein response on the production of recombinant proteins in plants.Plant cell reports · 2015Review
- RNA sequencing-mediated transcriptome analysis of rice plants in endoplasmic reticulum stress conditions.BMC plant biology · 2014Article
- The non-homologous end-joining pathway is involved in stable transformation in rice.Frontiers in plant science · 2014Review
- Effect of overexpression of kinase- or RNase-deficient OsIRE1 on the endoplasmic reticulum stress response in transgenic rice plants.Plant signaling & behavior · 2013Article
- Recent advances in understanding the control of secretory proteins by the unfolded protein response in plants.International journal of molecular sciences · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endoplasmic reticulum (ER) stress sensor, IRE1, contains a kinase domain and a ribonuclease domain. Ribonuclease mediates the unconventional splicing of mRNA encoding the transcription factor AtbZIP60 in Arabidopsis, or OsbZIP50 in rice, and thereby transduces signals from stressed ER. Here, we demonstrate the additional roles of plant IRE1 using genetically modified rice plants. Using a gene targeting system based on homologous recombination, genomic IRE1 was replaced with two types of missense alleles, leading to a defect in the kinase or ribonuclease activity of IRE1. Genetic analysis of these alleles demonstrated that the kinase activity of IRE1 plays a vital role independent of ribonuclease activity. Furthermore, the existence of ribonuclease substrates other than OsbZIP50 mRNA is demonstrated for the first time. This study provides new insights into higher plant signalling using a gene targeting approach.
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