ArticleJournal of preventive medicine and public health = Yebang Uihakhoe chi2012
Association of homocysteine levels with blood lead levels and micronutrients in the US general population.
Article in Journal of preventive medicine and public health = Yebang Uihakhoe chi, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Associations of Blood Lead Concentrations with Ferritin, Vitamin B12, and Homocysteine Levels in Mexican Preschool Children: A Nationally Representative Study.Biological trace element research · 2026Article
- Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.Metabolites · 2026Review
- First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.Environment international · 2024Article
- Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality.Cardiovascular toxicology · 2024Article
- Prevalence of hyperhomocysteinemia (HHcy) and its major determinants among hypertensive patients over 35 years of age.European journal of clinical nutrition · 2022Article
- How Should We Teach Nutrition to Health Care Professionals?Integrative medicine (Encinitas, Calif.) · 2022Article
- Plasma Vitamin BNutrients · 2021Article
- Lead (Pb) exposure and heart failure risk.Environmental science and pollution research international · 2021Review
- Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation.Arhiv za higijenu rada i toksikologiju · 2020Article
- Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults.BMJ nutrition, prevention & health · 2020Article
- Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States.Scientific reports · 2020Article
- Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?Antioxidants (Basel, Switzerland) · 2019Review
- Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study.Environmental health : a global access science source · 2017Article
- Evaluation and management of lead exposure.Annals of occupational and environmental medicine · 2015Review
- Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.Environmental health perspectives · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEven though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels.
methodsThis study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004.
resultsThere were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 µmol/L) as the outcome, there were similar patterns of interaction, though p-values for each interaction failed to reach statistical significance.
conclusionsIn the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.