ArticleThe Journal of physiology2013
Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Effects of high intensity interval exercise on cerebrovascular function: A systematic review.PloS one · 2020Pooled it
- Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial.The American journal of clinical nutrition · 2023Trial
- The influence of physical exercise and leisure activity on neuropsychological functioning in older adults.Age (Dordrecht, Netherlands) · 2015Trial
- Aerobic exercise and attention deficit hyperactivity disorder: brain research.Medicine and science in sports and exercise · 2015Trial
- Physical activity and the aging brain: A narrative review.Journal of health psychology · 2026Review
- Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Cerebral oxygen extraction across different exercise intensities: Role of arterialExperimental physiology · 2025Article
- Deconditioning in quiescent Crohn's disease patients with heightened fatigue perception.Journal of Crohn's & colitis · 2025Article
- Brain Oxygenation During Exercise in Different Types of Chronic Lung Disease: A Narrative Review.Sports (Basel, Switzerland) · 2025Review
- Changes in Functional Connectivity Between Default Mode Network and Attention Network in Response to Changes in Aerobic Exercise Intensity.Psychiatry investigation · 2023Article
- Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Trans-cerebral HCOJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Review
- Temporal changes in cortical oxygenation in the motor-related areas and bilateral prefrontal cortex based on exercise intensity and respiratory metabolism during incremental exercise in male subjects: A near-Infrared spectroscopy study.Frontiers in physiology · 2022Article
- Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation.Physiological reviews · 2021Review
- Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Vertebral artery hypoplasia influences age-related differences in blood flow of the large intracranial arteries.Aging brain · 2021Article
- Pharmacokinetic Principles and Their Application to Central Nervous System Tumors.Pharmaceutics · 2020Review
- Contribution of oxygen extraction fraction to maximal oxygen uptake in healthy young men.Acta physiologica (Oxford, England) · 2020Review
- Measurement and Changes in Cerebral Oxygenation and Blood Flow at Rest and During Exercise in Normotensive and Hypertensive Individuals.Current hypertension reports · 2020Review
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
We evaluated cerebral perfusion, oxygenation and metabolism in 11 young (22 ± 1 years) and nine older (66 ± 2 years) individuals at rest and during cycling exercise at low (25% W(max)), moderate (50% Wmax), high (75% W(max)) and exhaustive (100% W(max)) workloads. Mean middle cerebral artery blood velocity (MCA V(mean)), mean arterial pressure (MAP), cardiac output (CO) and partial pressure of arterial carbon dioxide (P(aCO2)) were measured. Blood samples were obtained from the right internal jugular vein and brachial artery to determine concentration differences for oxygen (O2), glucose and lactate across the brain. The molar ratio between cerebral uptake of O2 versus carbohydrate (O2-carbohydrate index; O2/[glucose + 1/2 lactate]; OCI), the cerebral metabolic rate of O2 (CMRO2) and changes in mitochondrial O2 tension ( P(mitoO2)) were calculated. 100% W(max) was ~33% lower in the older group. Exercise increased MAP and CO in both groups (P < 0.05 vs. rest), but at each intensity MAP was higher and CO lower in the older group (P < 0.05). MCA V(mean), P(aCO2) and cerebral vascular conductance index (MCA V(mean)/MAP) were lower in the older group at each exercise intensity (P < 0.05). In contrast, young and older individuals exhibited similar increases in CMRO2 (by ~30 μmol (100 g(-1)) min(-1)), and decreases in OCI (by ~1.5) and (by ~10 mmHg) during exercise at 75% W(max). Thus, despite the older group having reduced cerebral perfusion and maximal exercise capacity, cerebral oxygenation and uptake of lactate and glucose are similar during exercise in young and older individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.