ReviewThe Journal of physiology2013
New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment.
Review in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Quantitative Meta-analysis of Olfactory Dysfunction in Epilepsy.Neuropsychology review · 2019Pooled it
- The Effects of Optogenetic Activation of Astrocytes on Spike-and-Wave Discharges in Genetic Absence Epileptic Rats.Annals of neurosciences · 2022Article
- Astrocytic modulation of potassium under seizures.Neural regeneration research · 2020Review
- Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Astroglial role in the pathophysiology of statusOncotarget · 2018Review
- Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy.Neurochemical research · 2017Review
- Does rapid and physiological astrocyte-neuron signalling amplify epileptic activity?The Journal of physiology · 2017Review
- Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.Frontiers in neuroscience · 2016Review
- Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain.Neural plasticity · 2016Review
- Initiation, Propagation, and Termination of Partial (Focal) Seizures.Cold Spring Harbor perspectives in medicine · 2015Review
- Novel astrocyte targets: new avenues for the therapeutic treatment of epilepsy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2015Review
- Sustained down-regulation of β-dystroglycan and associated dysfunctions of astrocytic endfeet in epileptic cerebral cortex.The Journal of biological chemistry · 2014Article
- Astrocytes in endocannabinoid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Mechanisms of epileptiform synchronization in cortical neuronal networks.Current medicinal chemistry · 2014Review
- Why do some brains seize? Molecular, cellular and network mechanisms.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Our current knowledge of the role of astrocytes in health and disease states supports the view that many physiological brain functions and neurological diseases are finely tuned, and in certain cases fully determined, by the continuous cross-talk between astrocytes and neurons. This novel way of interpreting brain activity as a dynamic and reciprocal interplay between astrocytic and neuronal networks has also influenced our understanding of epilepsy, not only forcing a reinterpretation of old findings, but also being a catalyst for novel experimentation. In this review, we summarize some of the recent studies that highlight these novel distinct contributions of astrocytes to the expression of convulsive and non-convulsive epileptiform discharges and seizures. The emerging picture suggests a general framework based on bilateral signalling between astrocytes and neurons for a fuller understanding of epileptogenic and epileptic mechanisms in the brain network. Astrocytes potentially represent targets for the development of those novel chemical entities with improved efficacy for the treatment of convulsive and non-convulsive epilepsy that expert groups have recognized as one of the key priorities for the management of epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.