ArticleAmerican journal of Alzheimer's disease and other dementias2013
Potential blood biomarker for disease severity in the Taiwanese population with Alzheimer's disease.
Article in American journal of Alzheimer's disease and other dementias, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Neuroinflammation as a Link in Parkinson's and Alzheimer's Diseases: A Systematic Review and Meta-Analysis.Aging and disease · 2024Pooled it
- The clinical correlation of proinflammatory and anti-inflammatory biomarkers with Alzheimer disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis.Scientific reports · 2018Pooled it
- Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Deciphering genetic causality between plasma BDNF and 91 circulating inflammatory proteins through bidirectional mendelian randomization.Scientific reports · 2025Article
- Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.Signal transduction and targeted therapy · 2025Review
- Rationale and Design of the PARTNER Trial: Partnered Rhythmic Rehabilitation for Enhanced Motor-Cognition in Prodromal Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging.International journal of molecular and cellular medicine · 2023Review
- An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients.International journal of molecular sciences · 2022Article
- Iron status and mental disorders: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Plasma Biomarkers of Alzheimer's Disease in African Americans.Journal of Alzheimer's disease : JAD · 2021Article
- Diagnostic Utility of Selected Serum Dementia Biomarkers: Amyloid β-40, Amyloid β-42, Tau Protein, and YKL-40: A Review.Journal of clinical medicine · 2020Review
- Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study.Journal of clinical medicine · 2019Article
- Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2018Article
- The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer's disease.Alzheimer's research & therapy · 2017Article
- COX-2 metabolic products, the prostaglandin IOncotarget · 2017Article
- Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer's disease.Scientific reports · 2017Article
- Serum IL-8 is a marker of white-matter hyperintensities in patients with Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Article
- Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies.Frontiers in aging neuroscience · 2017Article
- Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease.Autoimmunity · 2015Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of blood biomarkers for Alzheimer's disease (AD) could contribute for improvement in early diagnosis. To define AD biomarkers, we compared serum/plasma levels of amyloid β (Aβ), tau, cytokines, and biometals between AD and non-AD groups. Cognitive impairment was assessed by Mini-Mental Status Examination (MMSE) and Clinical Dementia Rating scales. Plasma concentrations of total Aβ, Aβ(42), tumor necrosis factor α (TNF-α), and interleukin 6 were quantified by immunoassays. Serum biometal concentrations were determined using flame atomic absorption spectrometry. We found that serum zinc (Zn) was lower in patients with AD. After controlling for age, the MMSE score correlated with both TNF-α and total Aβ levels in the AD group, while the MMSE score correlated with iron only in the non-AD group. Our finding that blood Zn, TNF-α, and total Aβ are possible biomarkers for AD diagnosis and prognosis validates the pervious publication on potential biomarker in the Taiwanese population.
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