Evidence map›Paper›PMID 23229846›Full record

Trial reportJAMA internal medicine2013

Translating the Diabetes Prevention Program lifestyle intervention for weight loss into primary care: a randomized trial.

Jun Ma, Veronica Yank, Lan Xiao, Philip W Lavori, Sandra R Wilson, Lisa G Rosas, Randall S Stafford

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00842426 (A Pilot of Customized Continuous Care Management of Obesity in Pre-Diabetics), which is not on this map. Cited by 177 papers, 31 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 31 pooled it
49.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00842426 phase2completednot on this map

A Pilot of Customized Continuous Care Management of Obesity in Pre-Diabetics

TypeinterventionalSponsorPalo Alto Medical FoundationRan2009 to 2011Enrolled241ConditionsObesity, Pre-diabetes, Metabolic SyndromeArmsSelf-management program (SM), Care management program (CM)
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 31 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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  6. A systematic review of inequalities in the uptake of, adherence to, and effectiveness of behavioral weight management interventions in adults.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jun MaDepartment of Health Services Research, Palo Alto Medical Foundation Research Institute, Palo Alto, CA 94301, USA. maj@pamfri.org
Veronica Yank
Lan Xiao
Philip W Lavori
Sandra R Wilson
Lisa G Rosas
Randall S Stafford

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
A Pilot of Customized Continuous Care Management of Obesity in Pre-DiabeticsR34DK080878 · NIDDK · PALO ALTO MEDICAL FOUNDATION RES INST · PI MA, JUN · 2009 to 2010
$489k
NCATS NIH HHS UL1 TR001085NCRR NIH HHS 1UL1 RR025744NCRR NIH HHS UL1 RR025744NIDDK NIH HHS R34 DK080878NIDDK NIH HHS R34DK080878
6 · The paper itself

Abstract

backgroundThe Diabetes Prevention Program (DPP) lifestyle intervention reduced the incidence of type 2 diabetes mellitus (DM) among high-risk adults by 58%, with weight loss as the dominant predictor. However, it has not been adequately translated into primary care.

methodsWe evaluated 2 adapted DPP lifestyle interventions among overweight or obese adults who were recruited from 1 primary care clinic and had pre-DM and/or metabolic syndrome. Participants were randomized to (1) a coach-led group intervention (n = 79), (2) a self-directed DVD intervention (n = 81), or (3) usual care (n = 81). During a 3-month intensive intervention phase, the DPP-based behavioral weight-loss curriculum was delivered by lifestyle coach-led small groups or home-based DVD. During the maintenance phase, participants in both interventions received lifestyle change coaching and support remotely-through secure email within an electronic health record system and the American Heart Association Heart360 website for weight and physical activity goal setting and self-monitoring. The primary outcome was change in body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) from baseline to 15 months.

resultsAt baseline, participants had a mean (SD) age of 52.9 (10.6) years and a mean BMI of 32.0 (5.4); 47% were female; 78%, non-Hispanic white; and 17%, Asian/Pacific Islander. At month 15, the mean ± SE change in BMI from baseline was -2.2 ± 0.3 in the coach-led group vs -0.9 ± 0.3 in the usual care group (P < .001) and -1.6 ± 0.3 in the self-directed group vs usual care (P = .02). The percentages of participants who achieved the 7% DPP-based weight-loss goal were 37.0% (P = .003) and 35.9% (P = .004) in the coach-led and self-directed groups, respectively, vs 14.4% in the usual care group. Both interventions also achieved greater net improvements in waist circumference and fasting plasma glucose level.

conclusionProven effective in a primary care setting, the 2 DPP-based lifestyle interventions are readily scalable and exportable with potential for substantial clinical and public health impact.

trial registrationclinicaltrials.gov Identifier: NCT00842426.

Indexed as

Primary Health CareWeight Reduction ProgramsAdultAgedDiabetes MellitusFemaleHumansMaleMetabolic SyndromeMiddle AgedPatient Acceptance of Health CareRisk FactorsRisk Reduction BehaviorSelf CareVideodisc Recording

Identifiers

PMID23229846
PMCPMC3856315
OpenAlexW2040895889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.