ArticleInternational journal of obesity (2005)2013
Energy expenditure in obese children with pseudohypoparathyroidism type 1a.
Article in International journal of obesity (2005), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism
Effects of Theophylline on cAMP Signaling in Children With Pseudohypoparathyroidism Type 1a
Phase 2 Study of Theophylline Treatment for Pseudohypoparathyroidism
Who cites it
22 citing papers in PubMed.
- Pattern of height and weight development in a large cohort of underage Chinese pseudohypoparathyroidism patients from a single center.Endocrine connections · 2026Article
- Natural History of Hyperphagia in Patients with Pseudohypoparathyroidism.Journal of clinical medicine · 2025Article
- Updates on Rare Genetic Variants, Genetic Testing, and Gene Therapy in Individuals With Obesity.Current obesity reports · 2024Review
- A Novel Maternally InheritedJCEM case reports · 2024Article
- Resting Energy Expenditure and Body Composition in Children and Adolescents With Genetic, Hypothalamic, Medication-Induced or Multifactorial Severe Obesity.Frontiers in endocrinology · 2022Observational
- Pseudohypoparathyroidism, acrodysostosis, progressive osseous heteroplasia: different names for the same spectrum of diseases?Endocrine · 2021Review
- Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders: An Updated Practical Tool for Physicians and Patients.Hormone research in paediatrics · 2020Review
- Management of pseudohypoparathyroidism.Current opinion in pediatrics · 2019Review
- Thyroid Hormone Action and Energy Expenditure.Journal of the Endocrine Society · 2019Review
- Pseudohypoparathyroidism.Endocrinology and metabolism clinics of North America · 2018Review
- Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism.The Journal of clinical endocrinology and metabolism · 2018Article
- Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.Nature reviews. Endocrinology · 2018Review
- Genetic and Epigenetic Defects at the GNAS Locus Lead to Distinct Patterns of Skeletal Growth but Similar Early-Onset Obesity.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Current Nomenclature of Pseudohypoparathyroidism: Inactivating Parathyroid Hormone/Parathyroid Hormone-Related Protein Signaling Disorder.Journal of clinical research in pediatric endocrinology · 2017Review
- Article
- Early-Onset Obesity: Unrecognized First Evidence for GNAS Mutations and Methylation Changes.The Journal of clinical endocrinology and metabolism · 2017Article
- Nonclassic features of pseudohypoparathyroidism type 1A.Current opinion in endocrinology, diabetes, and obesity · 2017Review
- Genetic and epigenetic alterations in the GNAS locus and clinical consequences in Pseudohypoparathyroidism: Italian common healthcare pathways adoption.Italian journal of pediatrics · 2016Article
- Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A.The Journal of clinical endocrinology and metabolism · 2016Article
- Insulin resistance is not associated with thermogenic effect of a high-fat meal in obese children.Nutrition research (New York, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextPatients with pseudohypoparathyroidism type 1a (PHP-1a) develop early-onset obesity. The abnormality in energy expenditure and/or energy intake responsible for this weight gain is unknown.
objectiveThe aim of this study was to evaluate energy expenditure in children with PHP-1a compared with obese controls. PATIENTS: We studied 6 obese females with PHP-1a and 17 obese female controls. Patients were recruited from a single academic center. MEASUREMENTS: Resting energy expenditure (REE) and thermogenic effect of a high fat meal were measured using whole room indirect calorimetry. Body composition was assessed using whole body dual energy x-ray absorptiometry. Fasting glucose, insulin, and hemoglobin A1C were measured.
resultsChildren with PHP-1a had decreased REE compared with obese controls (P<0.01). After adjustment for fat-free mass, the PHP-1a group's REE was 346.4 kcals day(-1) less than obese controls (95% CI (-585.5--106.9), P<0.01). The thermogenic effect of food (TEF), expressed as percent increase in postprandial energy expenditure over REE, was lower in PHP-1a patients than obese controls, but did not reach statistical significance (absolute reduction of 5.9%, 95% CI (-12.2-0.3%), P=0.06).
conclusionsOur data indicate that children with PHP-1a have decreased REE compared with the obese controls, and that may contribute to the development of obesity in these children. These patients may also have abnormal diet-induced thermogenesis in response to a high-fat meal. Understanding the causes of obesity in PHP-1a may allow for targeted nutritional or pharmacologic treatments in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.