ArticleEuropean journal of immunology2013
E-cadherin: from epithelial glue to immunological regulator.
Article in European journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- O-Mannose Glycosylations Influence E-Cadherin Functional Interactions.Molecular & cellular proteomics : MCP · 2026Article
- Review
- Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root.Molecules (Basel, Switzerland) · 2023Article
- Ovol1/2 loss-induced epidermal defects elicit skin immune activation and alter global metabolism.EMBO reports · 2023Article
- Innate lymphoid cells: a new key player in atopic dermatitis.Frontiers in immunology · 2023Review
- CTLs Get SMAD When Pathogens Tell Them Where to Go.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Immune-Regulatory and Molecular Effects of Antidepressants on the Inflamed Human Keratinocyte HaCaT Cell Line.Neurotoxicity research · 2021Article
- The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis.Journal of cellular and molecular medicine · 2020Review
- Differential Effects of Dietary Supplementation of Krill Meal, Soybean Meal, Butyrate, and BactocellInternational journal of molecular sciences · 2020Article
- Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models.International journal of molecular medicine · 2019Article
- αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.Tissue barriers · 2018Review
- TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota.Journal of gastroenterology · 2017Review
- CD103Frontiers in immunology · 2017Article
- Heterocellular cadherin connections: coordinating adhesive cues in homeostasis and cancer.F1000Research · 2017Review
- E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.Scientific reports · 2015Article
- β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.The Journal of clinical investigation · 2014Article
- Adhesion Molecules in Non-melanoma Skin Cancers: A Comprehensive Review.In vivo (Athens, Greece)Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E-cadherin is best known as a central molecule in adherens junctions, joining adjacent epithelial cells together, thereby safeguarding epithelial barrier function. However, recent findings have uncovered an immunological role for this adhesion molecule, linked to its expression in dendritic cells (DCs) and alternatively activated macrophages (MPHs) and its impact on intracellular signaling pathways. In this respect, E-cadherin has been shown to influence the immunogenicity/tolerogenicity of DCs through the regulation of β-catenin functionality. For Langerhans cells (LCs), the DC type found in the skin epidermis, E-cadherin is known to mediate interactions with keratinocytes (KCs), thereby immobilizing immature LCs in the epidermis and preventing their maturation. In this issue of the European Journal of Immunology, a study by Mayumi et al. [Eur. J. Immunol. 2013. 43: 270-280] now describes a role for E-cadherin in the final steps of LC differentiation from human peripheral blood monocytes. Although TGF-β induces LC-like cells, these intermediates still express the dermal DC marker DC-SIGN along with Langerin; E-cadherin ligation is sufficient to induce the full LC phenotype in these cells. Here, we place these findings in the context of current knowledge and propose new avenues for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.