ArticleEuropean archives of psychiatry and clinical neuroscience2013
Neuropathological changes in the nucleus basalis in schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.Molecular psychiatry · 2016Pooled it
- The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations.Frontiers in aging neuroscience · 2024Review
- Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis.Translational psychiatry · 2022Article
- Investigating the contribution of cytoarchitecture to diffusion MRI measures in gray matter using histology.Frontiers in neuroimaging · 2022Article
- Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development.International journal of molecular sciences · 2021Review
- Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.Molecular autism · 2020Article
- Axonal myelin decrease in the splenium in major depressive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Alterations of Astrocytes in the Context of Schizophrenic Dementia.Frontiers in pharmacology · 2019Review
- (Micro)Glia as Effectors of Cortical Volume Loss in Schizophrenia.Schizophrenia bulletin · 2018Review
- The neurobiology of transition to psychosis: clearing the cache.Journal of psychiatry & neuroscience : JPN · 2017Article
- Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study.BMC psychiatry · 2017Article
- The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening.Frontiers in cell and developmental biology · 2017Review
- Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia.Molecular psychiatry · 2017Review
- Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease.Acta neuropathologica · 2015Review
- Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia.European archives of psychiatry and clinical neuroscience · 2014Article
- Impact of lifestyle in severe psychiatric disorders and brain morphology.European archives of psychiatry and clinical neuroscience · 2013Article
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
The nucleus basalis has not been examined in detail in severe mental illness. Several studies have demonstrated decreases in glia and glial markers in the cerebral cortex in schizophrenia, familial bipolar disorder and recurrent depression. Changes in neocortical neuron size and shape have also been reported. The nucleus basalis is a collection of large cholinergic neurons in the basal forebrain receiving information from the midbrain and limbic system, projecting to the cortex and involved with attention, learning and memory, and receives regulation from serotonergic inputs. Forty-one cases aged 41-60 years with schizophrenia or major depressive disorder with age-matched controls were collected. Formalin-fixed paraffin-embedded coronal nucleus basalis sections were histologically stained for oligodendrocyte identification with cresyl-haematoxylin counterstain, for neuroarchitecture with differentiated cresyl violet stain and astrocytes were detected by glial fibrillary acid protein immunohistochemistry. Cell density and neuroarchitecture were measured using Image Pro Plus. There were larger NB oval neuron soma in the combined schizophrenia and major depression disorder groups (p = 0.038), with no significant change between controls and schizophrenia and major depression disorder separately. There is a significant reduction in oligodendrocyte density (p = 0.038) in the nucleus basalis in schizophrenia. The ratio of gemistocytic to fibrillary astrocytes showed a greater proportion of the former in schizophrenia (18.1 %) and major depressive disorder (39.9 %) than in controls (7.9 %). These results suggest glial cell abnormalities in the nucleus basalis in schizophrenia possibly leading to cortical-limbic disturbance and subcortical dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.