ArticleMycopathologia2013
In vitro susceptibility of environmental isolates of Exophiala dermatitidis to five antifungal drugs.
Article in Mycopathologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Yeasts in the nests of the leaf-cutter ant Acromyrmex balzani in a Savanna biome: exploitation of community and metabolic diversity.Antonie van Leeuwenhoek · 2021Article
- Review
- Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis.Antimicrobial agents and chemotherapy · 2018Article
- A case ofJMM case reports · 2017Article
- Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy.BMC oral health · 2015Article
- Black yeast diversity on creosoted railway sleepers changes with ambient climatic conditions.Microbial ecology · 2014Article
- The bright future of darkness--the rising power of black fungi: black yeasts, microcolonial fungi, and their relatives.Mycopathologia · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Several dematiaceous fungi frequently isolated from nature are involved in cases of superficial lesions to lethal cerebral infections. Antifungal susceptibility data on environmental and clinical isolates are still sparse despite the advances in testing methods. The objective of this study was to examine the activities of 5-flucytosine, amphotericin B, itraconazole, voriconazole and terbinafine against environmental isolates of Exophiala strains by minimum inhibition concentration (MIC) determination. The strains were obtained from hydrocarbon-contaminated soil, ant cuticle and fungal pellets from the infrabuccal pocket of attine gynes. Broth microdilution assay using M38-A2 reference methodology for the five antifungal drugs and DNA sequencing for fungal identification were applied. Terbinafine was the most active drug against the tested strains. It was observed that amphotericin B was less effective, notably against Exophiala spinifera, also studied. High MICs of 5-flucytosine against Exophiala dermatitidis occurred. This finding highlights the relevance of studies on the antifungal resistance of these potential opportunistic species. Our results also contribute to a future improvement of the standard methods to access the drug efficacy currently applied to black fungi.
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