Evidence map›Paper›PMID 23229577›Full record

ArticleWiener klinische Wochenschrift2012

Therapeutic hypothermia for severe adult Herpes simplex virus encephalitis.

Marko Kutleša, Bruno Baršić

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Wiener klinische Wochenschrift, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marko KutlešaDepartment of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases Dr. Fran Mihaljević, University of Zagreb School of Medicine, Mirogojska 8, 10000, Zagreb, Croatia. mkutlesa@bfm.hr
Bruno Baršić
University Hospital for Infectious Diseases "Dr Fran Mihaljevic" · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite antiviral treatment and advances in critical care, the Herpes simplex encephalitis (HSE) still has a poor outcome in a significant portion of patients. In severe cases of HSE, reduced carbon dioxide reactivity is usually present and these patients don't respond to the usual treatment of brain edema and intracranial hypertension. We present case series of patients with severe form of HSE treated with therapeutic hypothermia (TH) and describe in detail the indications, methods, and the rationale for its use. In this case series, patients presented with severely impaired consciousness and very high predicted death rate as measured by Glasgow coma scale and Acute Physiology and Chronic Health Evaluation (APACHE II) score respectively. According to our findings, TH in carefully selected patients with HSE holds promise as an adjunctive to the antiviral treatment.

Indexed as

AcyclovirAgedAntiviral AgentsBrain EdemaCarbon DioxideDisease ProgressionEncephalitis, Herpes SimplexEncephaloceleGlasgow Coma ScaleHumansHypothermia, InducedInfusions, IntravenousMaleMiddle AgedOptic NerveOximetryAcyclovirAntiviral AgentsCarbon Dioxide

Identifiers

PMID23229577
OpenAlexW166506070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.