ArticleThe Journal of biological chemistry2013
Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis.PLoS biology · 2020Article
- Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- microRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans.Scientific reports · 2015Article
- A HIF-independent mediator of transcriptional responses to oxygen deprivation in Caenorhabditis elegans.Genetics · 2015Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans.Molecular and cellular biology · 2014Article
- The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.Journal of neurochemistry · 2014Article
- Article
- Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.British journal of pharmacology · 2013Review
- Calcium Supplementation Ameliorates Cerebellar Oxidative Stress in Lactational Aluminum-induced Neurotoxicity in Rats.Basic and clinical neuroscienceArticle
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxygen deprivation is accompanied by the coordinated expression of numerous hypoxia-responsive genes, many of which are controlled by hypoxia-inducible factor-1 (HIF-1). However, the cellular response to hypoxia is not likely to be mediated by HIF-1 alone, and little is known about HIF-1-independent hypoxia responses. To better establish the molecular mechanisms of HIF-1-independent hypoxia responses, we sought to characterize the molecular basis of the hypoxia response of the hsp-16.1 gene in the nematode Caenorhabditis elegans; this gene has been shown to be induced by hypoxia independently of hif-1. Using affinity purification followed by LC-MS/MS, we identified HMG-1.2 as a protein that binds to a specific promoter region under hypoxic conditions. By systematic prediction followed by validation of these interactions through RNAi, we identified the chromatin modifiers isw-1 and hda-1, histone H4, and NURF-1 chromatin-remodeling factors as new components of the hif-1-independent hypoxia response. These data suggest that the modulation of nucleosome positioning at the hsp-16.1 promoter may be important for the hypoxia response. In addition, we found that calcineurin acts independently of hif-1 to modulate the cellular response to hypoxia and that calcium ions are necessary for the induction of hsp-16.1 under hypoxic conditions.
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