Evidence map›Paper›PMID 23229471›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013

Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe.

E M Brouwer-Brolsma, H A Bischoff-Ferrari, R Bouillon, E J M Feskens, C J Gallagher, E Hypponen, D J Llewellyn, E Stoecklin, J Dierkes, A K Kies and 10 more

Abstract readConsensus Statement
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2017
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  9. Vitamin D and cardiovascular diseases: A narrative review.Journal of family medicine and primary care · 2024
    Review
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  11. Vitamin D in Neurological Diseases.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 9 countries.

E M Brouwer-BrolsmaDivision of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700, EV, Wageningen, The Netherlands. elske.brouwer@wur.nl
H A Bischoff-Ferrari
R Bouillon
E J M Feskens
C J Gallagher
E Hypponen
D J Llewellyn
E Stoecklin
J Dierkes
A K Kies
F J Kok
C Lamberg-Allardt
U Moser
S Pilz
W H Saris
N M van Schoor
P Weber
R Witkamp
A Zittermann
L C P G M de Groot
Wageningen University & Research · NLDSM (Netherlands) · NLAmsterdam UMC Location VUmc · NLCreighton University · USKU Leuven · BEMedical University of Graz · ATRuhr University Bochum · DEUnité de Nutrition Humaine · FRUniversity of Bergen · NOUniversity of Exeter · GBUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledOn September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized.

introductionSeveral groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive.

methodsTo exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized.

resultsDespite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population.

conclusionTo reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.

Indexed as

Dietary SupplementsDietEuropeEvidence-Based MedicineGlobal HealthHumansReference ValuesSunlightVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D

Identifiers

PMID23229471
OpenAlexW2093622873

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.