ArticlePediatric surgery international2013
Mesenteric neovascularization with distraction-induced intestinal growth: enterogenesis.
Article in Pediatric surgery international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration.Bioengineering (Basel, Switzerland) · 2025Article
- Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Administration of 4% tetrasodium EDTA lock solution and central venous catheter complications in high-risk pediatric patients with intestinal failure: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Generation of Porcine Ileum Through Spring-Mediated Mechanical Distraction.The Journal of surgical research · 2022Article
- Self-expanding intestinal expansion sleeves (IES) for short gut syndrome.Pediatric surgery international · 2022Article
- Review
- Development of an endoluminal intestinal attachment for a clinically applicable distraction enterogenesis device.Journal of pediatric surgery · 2016Article
- Development of an endoluminal intestinal lengthening device using a geometric intestinal attachment approach.Surgery · 2015Article
- A novel double-balloon catheter device for fully endoluminal intestinal lengthening.Pediatric surgery international · 2014Article
- Glucagon-like peptide 2 increases efficacy of distraction enterogenesis.The Journal of surgical research · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDistraction-induced enterogenesis, whereby the intestine lengthens with application of linear forces, is an emerging area which may provide a unique treatment for short bowel syndrome. With an increase in overall tissue mass, there is an increase in oxygen and nutrient demand. We hypothesized that a neovascularization within the mesentery is necessary to support the growing small bowel.
methodsA curvilinear hydraulic device was used to induce growth within the small bowel of Yorkshire pigs, and the intestine was harvested after 14 days. High-resolution gross pictures were recorded of the mesentery at implantation and at harvest, and CT imaging of the bowel and mesentery was performed at harvest after dye injection.
resultsAfter 2 weeks of distraction, an average of 72.5 % (8.7 cm) bowel lengthening was achieved. Gross images of the mesentery between major vessels showed a blossoming of the microvasculature and this was confirmed by CT imaging with 3D reconstruction. Mesenteric sample taken from the distracted segment had a fourfold increase in the volume of microvasculature versus controls.
conclusionEnterogenesis results not only in increased bowel length, but also significant increase in the mesenteric microvascularity. Presumably, this sustains the lengthened segment after application of longitudinal forces.
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Registered trials
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