ReviewAnnals of biomedical engineering2013
High wall shear stress and spatial gradients in vascular pathology: a review.
Review in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06249373 (A Multicenter Randomized Controlled Trial on the Effect of Low-intensity Pulsed Ultrasound on the Maturation of Newly Constructed Autogenous Arteriovenous Fistulas in Uremic Patients), which is not on this map. Cited by 173 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Randomized Controlled Trial on the Effect of Low-intensity Pulsed Ultrasound on the Maturation of Newly Constructed Autogenous Arteriovenous Fistulas in Uremic Patients
Who cites it
173 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of thrombectomy with or without intravenous thrombolysis in the treatment of acute basilar artery occlusion ischemic stroke: an updated systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- Association between basilar artery configuration and Vessel Wall features: a prospective high-resolution magnetic resonance imaging study.BMC medical imaging · 2019Trial
- Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double-Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease.Journal of the American Heart Association · 2016Trial
- Possible hemodynamic mechanisms in the size change of cerebral aneurysms: an exploratory study.Quantitative imaging in medicine and surgery · 2026Article
- Hemodynamic Metrics and Arterial Dysfunction: Insights From a Novel Microfluidic Device.International journal for numerical methods in biomedical engineering · 2026Article
- Reactive oxygen species in thoracic aortic dissection: Insights into mechanisms and disease progression.Redox biology · 2026Review
- IGF-1 Inhibits the Hemodynamics‑Induced Progression of Intracranial Aneurysms by Modulating the Proliferation and Apoptosis of Vascular Smooth Muscle Cells.Translational stroke research · 2026Article
- Impact of geometric factors and shear stress on endothelial function: Hemodynamic insights from human cerebral arterial bifurcations.Physiological reports · 2026Article
- Machine Learning Models for Objective Assessment of Vascular Anastomoses Using Computational Fluid Dynamics for Surgical Skill Training-A Retrospective Study.Journal of clinical medicine · 2026Article
- Retinal arteriovenous crossings as spatiotemporal stress fields: a quantitative Doppler OCT flowmetry study.Scientific reports · 2026Article
- Intravascular ultrasound wall shear stress imaging in stented coronary arteries with ultrafast Doppler.Scientific reports · 2026Article
- Biology, Physics, and Genetics of Intracranial Aneurysm Formation: A Review.Journal of neurological surgery. Part A, Central European neurosurgery · 2026Review
- Associations Between Hemodynamics, Shape and Atherosclerosis in M1 of Middle Cerebral Artery: Insights From 4-Dimensional Flow Magnetic Resonance Imaging in Patients With Ischemic Stroke.Journal of the American Heart Association · 2026Article
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- How do age, sex, and carotid segment influence carotid ultrasonography based on vector flow imaging and radiofrequency analysis in healthy subjects?BMC medical imaging · 2026Article
- Postoperative Rebleeding: The Sword of Damocles in Minimally Invasive Surgery for Intracerebral Hemorrhage.Research (Washington, D.C.) · 2026Review
- Article
- Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces.Bioengineering & translational medicine · 2026Article
- Association of intraluminal thrombus in thoracoabdominal aortic aneurysms with a blood stasis model.Frontiers in cardiovascular medicine · 2026Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cardiovascular pathologies such as intracranial aneurysms (IAs) and atherosclerosis preferentially localize to bifurcations and curvatures where hemodynamics are complex. While extensive knowledge about low wall shear stress (WSS) has been generated in the past, due to its strong relevance to atherogenesis, high WSS (typically >3 Pa) has emerged as a key regulator of vascular biology and pathology as well, receiving renewed interests. As reviewed here, chronic high WSS not only stimulates adaptive outward remodeling, but also contributes to saccular IA formation (at bifurcation apices or outer curves) and atherosclerotic plaque destabilization (in stenosed vessels). Recent advances in understanding IA pathogenesis have shed new light on the role of high WSS in pathological vascular remodeling. In complex geometries, high WSS can couple with significant spatial WSS gradient (WSSG). A combination of high WSS and positive WSSG has been shown to trigger aneurysm initiation. Since endothelial cells (ECs) are sensors of WSS, we have begun to elucidate EC responses to high WSS alone and in combination with WSSG. Understanding such responses will provide insight into not only aneurysm formation, but also plaque destabilization and other vascular pathologies and potentially lead to improved strategies for disease management and novel targets for pharmacological intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.