Trial reportInternational urology and nephrology2014
Preservation of residual renal function by not removing water in new hemodialysis patients: a randomized, controlled study.
Trial report in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Left ventricular mass regression, all-cause and cardiovascular mortality in chronic kidney disease: a meta-analysis.BMC nephrology · 2022Pooled it
- Efficacy and safety of oral tolvaptan in patients undergoing hemodialysis: a Phase 2, double-blind, randomized, placebo-controlled trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Trial
- Residual Kidney Function in Hemodialysis: Its Importance and Contribution to Improved Patient Outcomes.Toxins · 2024Review
- On the importance of the interplay of residual renal function with clinical outcomes in end-stage kidney disease.Journal of nephrology · 2022Review
- Is incremental hemodialysis ready to return on the scene? From empiricism to kinetic modelling.Journal of nephrology · 2017Review
- Residual Kidney Function Decline and Mortality in Incident Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2016Article
- Will incremental hemodialysis preserve residual function and improve patient survival?Seminars in dialysisArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of no water removal (NWR) on preservation of residual renal function (RRF) in new hemodialysis (HD) patients.
methodsFifty-six patients with a daily urine volume ≥ 1,000 mL were included. Patients were randomized to different fluid management groups of NWR or water removal (WR) for 6 months. If predialysis BP was >150/90 mmHg, patients could take antihypertensive drugs. The primary endpoints included death, cardio-cerebral vascular disease, refractory hypertension, and edema or an auxiliary examination indicating obvious fluid retention. The secondary endpoint was oliguria. A daily urine volume, 24-h urine creatinine clearance, the defined daily dose (DDD) index of antihypertensive drugs, erythropoietin resistance index, cardiothoracic ratio, and left ventricular mass index (LVMI) were recorded.
resultsEight patients in the NWR group reached the primary endpoints. Nine patients in the WR group reached the secondary endpoint. At the end of the study, patients in the NWR group had more increased systemic blood pressure (9.0 ± 8.3 vs. -2.4 ± 2.0 mmHg, p < 0.001), DDD index (1.2 ± 1.02 vs. -0.9 ± 0.51, p < 0.001), daily urine volume (164 ± 351 vs. -726 ± 342 mL, p < 0.001), cardiothoracic ratio (0.02 ± 0.04 vs. -0.03 ± 0.03, p < 0.001), LVMI (9.6 ± 17.0 vs. -12.0 ± 21.4 g/m(2), p < 0.001), and less decreased urine creatinine clearance (-1.0 ± 0.4 vs. -2.0 ± 1.0, p < 0.001), compared with those patients in the WR group.
conclusionsPreservation of RRF by NWR is warranted in new HD patients, but is not appropriate for all patients.
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