ArticleDevelopmental biology2013
A novel FoxD3 gene trap line reveals neural crest precursor movement and a role for FoxD3 in their specification.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Advancing knock-in approaches for robust genome editing in zebrafish.Biology open · 2026Article
- MEP glia share molecular features with oligodendrocytes while maintaining a distinct hybrid signature.microPublication biology · 2026Article
- Advancing Knock-In Approaches for Robust Genome Editing in Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- From neural crest migration to the onset of gangliogenesis.Current topics in developmental biology · 2025Review
- MicroRNAs in neural crest development and neurocristopathies.Biochemical Society transactions · 2022Review
- Notch controls the cell cycle to define leader versus follower identities during collective cell migration.eLife · 2022Article
- The Polycomb group geneFrontiers in neuroscience · 2022Article
- NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration.Nature communications · 2021Article
- Glutamate Signaling via the AMPAR Subunit GluR4 Regulates Oligodendrocyte Progenitor Cell Migration in the Developing Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia.eLife · 2021Article
- The Cranial Neural Crest in a Multiomics Era.Frontiers in physiology · 2021Article
- Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric Neuronal Development in Zebrafish.Frontiers in cell and developmental biology · 2021Article
- FGF2 Stimulates the Growth and Improves the Melanocytic Commitment of Trunk Neural Crest Cells.Cellular and molecular neurobiology · 2020Article
- Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair.Nature communications · 2020Article
- Article
- From Pioneer to Repressor: Bimodal foxd3 Activity Dynamically Remodels Neural Crest Regulatory Landscape In Vivo.Developmental cell · 2018Article
- Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.Neural development · 2018Article
- Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin.Frontiers in cellular neuroscience · 2018Review
- Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis.Disease models & mechanisms · 2016Article
- FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.Cell stem cell · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neural crest cells migrate extensively and contribute to diverse derivatives, including the craniofacial skeleton, peripheral neurons and glia, and pigment cells. Although several transgenic lines label neural crest subpopulations, few are suited for studying early events in neural crest development. Here, we present a zebrafish gene/protein trap line gt(foxd3-citrine)(ct110a) that expresses a Citrine fusion protein with FoxD3, a transcription factor expressed in premigratory and migrating neural crest cells. In this novel line, citrine expression exactly parallels endogenous foxd3 expression. High-resolution time-lapse imaging reveals the dynamic phases of precursor and migratory neural crest cell movements from the neural keel stage to times of active cell migration. In addition, Cre-recombination produces a variant line FoxD3-mCherry-pA whose homozygosis generates a FoxD3 mutant. Taking advantage of the endogenously regulated expression of FoxD3-mCherry fusion protein, we directly assess early effects of FoxD3 loss-of-function on specification and morphogenesis of dorsal root ganglia, craniofacial skeleton and melanophores. These novel lines provide new insights and useful new tools for studying specification, migration and differentiation of neural crest cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.