ArticleNeuroImage2013
Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation.European archives of psychiatry and clinical neuroscience · 2023Trial
- Cortical dopamine reduces the impact of motivational biases governing automated behaviour.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Trial
- Integrating Pharmacovigilance Data Mining and Mendelian Randomization to Identify Risk Profiles and Causal Targets of Opioid-Induced Delirium.CNS neuroscience & therapeutics · 2026Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility.Biomolecules · 2025Article
- Dopaminergic Epistases in Schizophrenia.Brain sciences · 2024Review
- Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease.Current research in translational medicine · 2024Article
- Childhood trauma and genetic variation in theIBRO neuroscience reports · 2022Article
- BDNF and KIBRA Polymorphisms Are Related to Altered Resting State Network Connectivity in Middle Age.Journal of Alzheimer's disease : JAD · 2022Article
- Article
- Interaction of Catechol-O-methyltransferase ValBrain and behavior · 2020Article
- Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children.Psychiatry investigation · 2020Article
- No association ofPeerJ · 2019Article
- Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats.Alcohol (Fayetteville, N.Y.) · 2018Article
- The Role of Frontostriatal Systems in Instructed Reinforcement Learning: Evidence From Genetic and Experimentally-Induced Variation.Frontiers in human neuroscience · 2018Article
- Adaptive testing for multiple traits in a proportional odds model with applications to detect SNP-brain network associations.Genetic epidemiology · 2017Article
- COMT ValFrontiers in human neuroscience · 2017Article
- Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Brain white matter structure and COMT gene are linked to second-language learning in adults.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance. A human COMT polymorphism (Val(158)Met) alters enzyme activity and is associated with both the activation and functional connectivity of the PFC during task performance, particularly working memory. Here, we used functional magnetic resonance imaging and a data-driven, independent components analysis (ICA) approach to compare resting state functional connectivity within the executive control network (ECN) between young, male COMT Val(158) (n=27) and Met(158) (n=28) homozygotes. COMT genotype effects on grey matter were assessed using voxel-based morphometry. COMT genotype significantly modulated functional connectivity within the ECN, which included the head of the caudate, and anterior cingulate and frontal cortical regions. Val(158) homozygotes showed greater functional connectivity between a cluster within the left ventrolateral PFC and the rest of the ECN (using a threshold of Z>2.3 and a family-wise error cluster significance level of p<0.05). This difference occurred in the absence of any alterations in grey matter. Our data show that COMT Val(158)Met affects the functional connectivity of the PFC at rest, complementing its prominent role in the activation and functional connectivity of this region during cognitive task performance. The results suggest that genotype-related differences in prefrontal dopaminergic tone result in neuroadaptive changes in basal functional connectivity, potentially including subtle COMT genotype-dependent differences in the relative coupling of task-positive and task-negative regions, which could in turn contribute to its effects on brain activation, connectivity, and behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.