ArticleCardiovascular diabetology2012
Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study.
Article in Cardiovascular diabetology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Circulating calcium levels and the risk of type 2 diabetes: a systematic review and meta-analysis.The British journal of nutrition · 2019Pooled it
- A systematic review of vitamin D status in southern European countries.European journal of nutrition · 2018Pooled it
- Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis.Nutrients · 2018Pooled it
- Obesity and cancer: the role of vitamin D.BMC cancer · 2014Pooled it
- Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study.BMC endocrine disorders · 2017Trial
- Expert-Reviewed Nutritional Guidance for Adults with Spinal Cord Injury: A Delphi Study.Nutrients · 2025Article
- Review
- Vitamin D Deficiency Is Associated with Impaired Sensitivity to Thyroid Hormones in Euthyroid Adults.Nutrients · 2023Article
- Calcium carbonate-enriched pumpkin affects calcium status in ovariectomized rats.Journal of food science and technology · 2023Article
- Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents.Children (Basel, Switzerland) · 2023Article
- Identification of Biomarkers Related to Metabolically Unhealthy Obesity in Korean Obese Adolescents: A Cross-Sectional Study.Children (Basel, Switzerland) · 2023Article
- The role of vitamin D in menopausal women's health.Frontiers in physiology · 2023Review
- PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment.Journal of clinical medicine · 2022Review
- Secondary Hyperparathyroidism Before and After Bariatric Surgery: a Prospective Study with 2-Year Follow-Up.Obesity surgery · 2022Article
- Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021Review
- Combined associations of 25-hydroxivitamin D and parathyroid hormone with diabetes risk and associated comorbidities among U.S. white and black women.Nutrition & diabetes · 2021Article
- Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease.Frontiers in pediatrics · 2021Review
- Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.Scientific reports · 2020Article
- Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity.Children (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow concentrations of plasma vitamin D (25(OH)D) have been associated with the development of metabolic syndrome (MetS), obesity, diabetes and cardiovascular disease. The objective of this study was to quantify the associations between 25(OH)D and parathormone (PTH) plasma levels and obesity, the presence of MetS, diabetes or atherogenic dyslipidemia (AD) in a large sample of individuals with different degrees of adiposity.
methodsRetrospective study of all patients who had attended the obesity clinics in a Spanish hospital between 2009 and 2011, and whose concentrations of PTH, 25(OH)D, calcium and alkaline phosphatase had been determined (n=316, 75.9% women). Individuals were categorized by degree of adiposity, presence of MetS, and other comorbidities.
resultsPTH increased but 25(OH)D and calcium decreased with increasing adiposity. The prevalence of 25(OH)D deficiency or insufficiency increased with obesity (<10% when BMI<45kg/m(2), and 26% when >50). The prevalence of hyperparathyroidism increased from 12% in non-obese to 47.5% in morbidly obese individuals with BMI>50 kg/m2. Low plasma 25(OH)D and high PTH concentrations were associated with an increased risk of MetS and AD. These associations disappeared, except in the case of AD for 25(OH)D when adjusting for BMI. Regression analysis revealed that BMI and age or seasonality were independent predictors of PTH and 25(OH)D levels, respectively.
conclusionsBMI was the variable most strongly associated with plasma 25(OH)D and PTH concentrations in our study. Low 25(OH)D and high PTH concentrations were not independently associated with an increased risk of MetS, or diabetes. Our data support a possible contribution of plasma 25(OH)D to the pathogenesis of hypertriglyceridemia and AD through inflammation.
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