ArticleBehavioral and brain functions : BBF2012
Marine Ο-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD.
Article in Behavioral and brain functions : BBF, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics.PloS one · 2013Trial
- The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders.CNS neuroscience & therapeutics · 2025Review
- Metabolomic Insights into Attention Deficit Hyperactivity Disorder: A Scoping Review.Metabolites · 2025Review
- The possible effects of chili peppers on ADHD in relation to the gut microbiota.Frontiers in nutrition · 2025Review
- Serotonin Signaling through Lipid Membranes.ACS chemical neuroscience · 2024Review
- The microbiota-gut-brain axis and neurodevelopmental disorders.Protein & cell · 2023Review
- The Effect of Very-Long-ChainNutrients · 2023Review
- Lipid metabolism in dopaminergic neurons influences light entrainment.Journal of neurochemistry · 2023Article
- The Microbiota-Gut-Brain Axis in Psychiatric Disorders.International journal of molecular sciences · 2022Review
- Impaired Local and Long-Range Brain Connectivity and Visual Response in a Genetic Rat Model of Hyperactivity Revealed by Functional Ultrasound.Frontiers in neuroscience · 2022Article
- Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders.Nutrients · 2021Review
- The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies.Journal of autism and developmental disorders · 2021Article
- Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications.Nutrients · 2021Review
- Sex Differences in Psychiatric Disease: A Focus on the Glutamate System.Frontiers in molecular neuroscience · 2018Review
- N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders.CNS & neurological disorders drug targets · 2018Review
- N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology.The international journal of neuropsychopharmacology · 2016Review
- Patterns of motor activity in spontaneously hypertensive rats compared to Wistar Kyoto rats.Behavioral and brain functions : BBF · 2016Article
- Effect of Poly Unsaturated Fatty Acids Administration on Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial.Journal of clinical and diagnostic research : JCDR · 2016Article
- A decade of contributions to understanding and ameliorating attention deficit-hyperactivity disorder.Behavioral and brain functions : BBF · 2016Review
- Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment.Neuropsychiatric disease and treatment · 2016Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious reports suggest that omega-3 (n-3) polyunsaturated fatty acids (PUFA) supplements may reduce ADHD-like behaviour. Our aim was to investigate potential effects of n-3 PUFA supplementation in an animal model of ADHD.
methodsWe used spontaneously hypertensive rats (SHR). SHR dams were given n-3 PUFA (EPA and DHA)-enriched feed (n-6/n-3 of 1:2.7) during pregnancy, with their offspring continuing on this diet until sacrificed. The SHR controls and Wistar Kyoto (WKY) control rats were given control-feed (n-6/n-3 of 7:1). During postnatal days (PND) 25-50, offspring were tested for reinforcement-dependent attention, impulsivity and hyperactivity as well as spontaneous locomotion. The animals were then sacrificed at PND 55-60 and their neostriata were analysed for monoamine and amino acid neurotransmitters with high performance liquid chromatography.
resultsn-3 PUFA supplementation significantly enhanced reinforcement-controlled attention and reduced lever-directed hyperactivity and impulsiveness in SHR males whereas the opposite or no effects were observed in females. Analysis of neostriata from the same animals showed significantly enhanced dopamine and serotonin turnover ratios in the male SHRs, whereas female SHRs showed no change, except for an intermediate increase in serotonin catabolism. In contrast, both male and female SHRs showed n-3 PUFA-induced reduction in non-reinforced spontaneous locomotion, and sex-independent changes in glycine levels and glutamate turnover.
conclusionsFeeding n-3 PUFAs to the ADHD model rats induced sex-specific changes in reinforcement-motivated behaviour and a sex-independent change in non-reinforcement-associated behaviour, which correlated with changes in presynaptic striatal monoamine and amino acid signalling, respectively. Thus, dietary n-3 PUFAs may partly ameliorate ADHD-like behaviour by reinforcement-induced mechanisms in males and partly via reinforcement-insensitive mechanisms in both sexes.
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