ArticleImmunology2013
CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.
Article in Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Genetic susceptibility of human leukocyte antigen alleles in chronic inflammatory demyelinating polyneuropathy in Korean patients : Short title: HLA alleles and CIDP in Korea.BMC neurology · 2025Article
- Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes.Nature communications · 2024Article
- Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas.Nature communications · 2024Article
- HLA-DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients.Journal of diabetes · 2023Article
- Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.Diabetes · 2023Article
- Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes.Frontiers in immunology · 2022Review
- Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis.Annals of clinical and translational neurology · 2021Article
- Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI insight · 2021Article
- A Question of Tolerance-Antigen-Specific Immunotherapy for Type 1 Diabetes.Current diabetes reports · 2020Review
- Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.Journal of neurology · 2020Article
- Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01.Diabetes · 2020Article
- Autoantigen Treatment in Type 1 Diabetes: Unsolved Questions on How to Select Autoantigen and Administration Route.International journal of molecular sciences · 2020Review
- Increased islet antigen-specific regulatory and effector CD4Science immunology · 2020Article
- DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.Journal of autoimmunity · 2018Article
- A Novel Approach of Identifying Immunodominant Self and Viral Antigen Cross-Reactive T Cells and Defining the Epitopes They Recognize.Frontiers in immunology · 2018Article
- Peptide Immunotherapy for Type 1 Diabetes-Clinical Advances.Frontiers in immunology · 2018Review
- Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development.Diabetes care · 2017Article
- Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.Nature communications · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Type 1 diabetes is associated with T-cell responses to β-cell antigens such as GAD65. Single T-cell epitopes have been investigated for immune monitoring with some success, but multiple epitopes may be required to fully characterize responses in all subjects. We used a systematic approach to examine the diversity of the GAD65-specific T-cell repertoire in subjects with DRB1*04:01 haplotypes. Using class II tetramers, we observed responses to 15 GAD65 epitopes, including five novel epitopes. The majority were confirmed to be processed and presented. Upon stimulation with peptides, GAD-specific responses were equally broad in subjects with diabetes and healthy controls in the presence or absence of CD25(+) T cells, suggesting that a susceptible HLA is sufficient to generate a potentially autoreactive repertoire. Without depleting CD25(+) cells, GAD(113-132) and GAD(265-284) responses were significantly stronger in subjects with diabetes. Although nearly every individual responded to at least one GAD65 epitope, most were seen in less than half of the subjects tested, suggesting that multiple epitopes are recommended for immune monitoring.
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