ArticleClinical proteomics2012
Urine proteome of autosomal dominant polycystic kidney disease patients.
Article in Clinical proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Immune microenvironment in autosomal dominant polycystic kidney disease.Genes & diseases · 2026Review
- Alterations of urinary proteomic profiles are correlated with return to sport after anterior cruciate ligament reconstruction.BMC sports science, medicine & rehabilitation · 2026Article
- Complex Pathophysiology of Acute Kidney Injury (AKI) in Aging: Epigenetic Regulation, Matrix Remodeling, and the Healing Effects of HBiomolecules · 2024Review
- Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease.JCI insight · 2024Article
- PRYNT: a tool for prioritization of disease candidates from proteomics data using a combination of shortest-path and random walk algorithms.Scientific reports · 2021Article
- Transcriptional and proteomic insights into phytotoxic activity of interspecific potato hybrids with low glycoalkaloid contents.BMC plant biology · 2021Article
- Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans.Journal of translational medicine · 2021Article
- Role of chemokines, innate and adaptive immunity.Cellular signalling · 2020Review
- Urine Proteomic Study in OAB Patients-Preliminary Report.Journal of clinical medicine · 2020Article
- Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease.International journal of molecular sciences · 2019Article
- Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring.Proteomics. Clinical applications · 2018Article
- Targeted Proteomics Approach Toward Understanding the Role of the Mitochondrial Protease FTSH4 in the Biogenesis of OXPHOS During Arabidopsis Seed Germination.Frontiers in plant science · 2018Article
- A Multiplexed Cytokeratin Analysis Using Targeted Mass Spectrometry Reveals Specific Profiles in Cancer-Related Pleural Effusions.Neoplasia (New York, N.Y.) · 2016Article
- Complement activation in progressive renal disease.World journal of nephrology · 2015Review
- Syringe-push membrane absorption as a simple rapid method of urine preparation for clinical proteomics.Clinical proteomics · 2015Article
- Evaluation of urinary protein precipitation protocols for the multidisciplinary approach to the study of chronic pelvic pain research network.Journal of biomolecular techniques : JBT · 2014Article
- Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain-clues for synaptic pathology.Molecular & cellular proteomics : MCP · 2014Article
- The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?Fibrogenesis & tissue repair · 2014Article
- Urinary proteomic and non-prefractionation quantitative phosphoproteomic analysis during pregnancy and non-pregnancy.BMC genomics · 2013Article
- Systems biology of polycystic kidney disease: a critical review.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutosomal dominant polycystic kidney disease (ADPKD) is responsible for 10% of cases of the end stage renal disease. Early diagnosis, especially of potential fast progressors would be of benefit for efficient planning of therapy. Urine excreted proteome has become a promising field of the search for marker patterns of renal diseases including ADPKD. Up to now however, only the low molecular weight fraction of ADPKD proteomic fingerprint was studied. The aim of our study was to characterize the higher molecular weight fraction of urinary proteome of ADPKD population in comparison to healthy controls as a part of a general effort aiming at exhaustive characterization of human urine proteome in health and disease, preceding establishment of clinically useful disease marker panel.
resultsWe have analyzed the protein composition of urine retentate (>10 kDa cutoff) from 30 ADPKD patients and an appropriate healthy control group by means of a gel-free relative quantitation of a set of more than 1400 proteins. We have identified an ADPKD-characteristic footprint of 155 proteins significantly up- or downrepresented in the urine of ADPKD patients. We have found changes in proteins of complement system, apolipoproteins, serpins, several growth factors in addition to known collagens and extracellular matrix components. For a subset of these proteins we have confirmed the results using an alternative analytical technique.
conclusionsObtained results provide basis for further characterization of pathomechanism underlying the observed differences and establishing the proteomic prognostic marker panel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.