ArticleBMC infectious diseases2012
Molecular typing and characterization of nasal carriage and community-onset infection methicillin-susceptible Staphylococcus aureus isolates in two Taiwan medical centers.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 47 citations in OpenAlex.
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- Characterization of Methicillin-ResistantPathogens (Basel, Switzerland) · 2022Article
- Carriage prevalence and genomic epidemiology ofMicrobial genomics · 2022Article
- Investigating Unfavorable Factors That Impede MALDI-TOF-Based AI in Predicting Antibiotic Resistance.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical Features and Molecular Characteristics of Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2021Article
- Nasal Methicillin-ResistantMicroorganisms · 2021Article
- Colonization withMicrobial genomics · 2021Article
- Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.Journal of clinical laboratory analysis · 2020Article
- Prevalence and Characteristics of Antimicrobial-ResistantFood science of animal resources · 2020Article
- Genotype distribution of methicillin-susceptible Staphylococcus aureus clinical isolates in Iran: high multiresistant clonal complex 8.BMC research notes · 2020Article
- Molecular characteristics and clinical features of pediatric methicillin-susceptible Staphylococcus aureus infection in a medical center in northern Taiwan.BMC infectious diseases · 2019Article
- Phylogenetic analysis and virulence determinant of the host-adapted Staphylococcus aureus lineage ST188 in China.Emerging microbes & infections · 2018Article
- Antibiotic Resistance Patterns and Virulence Determinants of Different SCCmec and Pulsotypes ofThe open microbiology journal · 2017Review
- Prevalence of and risk factors for methicillin-resistantJournal of oral microbiology · 2017Article
- Molecular Characteristics ofFrontiers in cellular and infection microbiology · 2017Article
- Toxigenic profile of methicillin-sensitive and resistant Staphylococcus aureus isolated from special groups.Annals of clinical microbiology and antimicrobials · 2016Article
- Molecular Characterization of a Prevalent Ribocluster of Methicillin-Sensitive Staphylococcus aureus from Orthopedic Implant Infections. Correspondence with MLST CC30.Frontiers in cellular and infection microbiology · 2016Article
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5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompared to methicillin-resistant Staphylococcus aureus (MRSA), characteristics of nasal carriage and community-onset infection methicillin-susceptible S. aureus (MSSA) are less well known. No characteristics of MSSA in Taiwan have been reported previously.
methodsWe analyzed 100 nasal carriage and 34 community-onset infection MSSA isolates by pulsed-field gel electrophoresis (PFGE), spa typing, multi-locus sequence typing, agr typing, virulence gene detection, growth rate measurement, and antimicrobial susceptibility.
resultsIn PFGE analysis, most (68%) infection isolates could be grouped in one major cluster using a 70% similarity cutoff. In contrast, only 17% of nasal carriage isolates belonged to this cluster. A similar classification was obtained using Based Upon Repeat Pattern analysis of spa types. The MSSA infection isolates cluster was closely related to the virulent clones of clonal complex 1 (CC1), which includes strains MW2 (USA400) and MSSA476. ST188 of CC1 was the predominant clone detected for community-onset MSSA infections. The only common ST type for MSSA and MRSA in Taiwan was ST59, the community-associated MRSA clone. It is likely, therefore, that MRSA originated from MSSA clones through SCCmec transfer. Compared to nasal carriage isolates, infection isolates less frequently possessed egc, tst and hlg genes, were more commonly susceptible to erythromycin (91% vs. 54%), and had shorter mean doubling times (38 min vs. 55 min).
conclusionsThe clonal lineages of MSSA nasal carriage and infection isolates differed in our sample of Taiwan isolates. Most community-onset MSSA infections resulted from relatively few clonal lineages. Nasal carriage isolates more frequently possessed the egc, tst and hlg genes, were more resistant to erythromycin, and grew more slowly.
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