ArticleParkinson's disease2012
Effect of deep brain stimulation on speech performance in Parkinson's disease.
Article in Parkinson's disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05493670 (Role of Subthalamic Nucleus in Speech and Movement Among People With Parkinson's Disease as Revealed by Intraoperative Recordings and Deep Brain Stimulation), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Subthalamic Nucleus in Speech and Movement Among People With Parkinson's Disease as Revealed by Intraoperative Recordings and Deep Brain Stimulation
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta-analysis.Movement disorders : official journal of the Movement Disorder Society · 2026Pooled it
- Speech, voice, and language outcomes following deep brain stimulation: A systematic review.PloS one · 2024Pooled it
- Baseline predictors of response to a group-based speech and communication intervention in Parkinson's disease: A secondary analysis of a randomized controlled trial.Journal of Parkinson's disease · 2026Trial
- Speech treatment in Parkinson's disease: Randomized controlled trial (RCT).Movement disorders : official journal of the Movement Disorder Society · 2018Trial
- Alpha-synuclein overexpression reduces neural activity within a basal ganglia vocal nucleus in a zebra finch model.PloS one · 2026Article
- Clinical predictors of speech changes after subthalamic neurostimulation in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Longitudinal Analysis of the Deep Brain Stimulation Impairment Scale for Subthalamic Nucleus Stimulation in Parkinson's Disease.Clinical parkinsonism & related disorders · 2025Article
- Effect of deep brain stimulation on dysphagia in Parkinson's disease: mechanisms, evidence, and outlook.Frontiers in aging neuroscience · 2025Review
- Automated Acoustic Analysis in Parkinson's Disease Using a SmartphoneAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- No differential effects of subthalamic nucleus vs. globus pallidus deep brain stimulation in Parkinson's disease: Speech acoustic and perceptual findings.IBRO neuroscience reports · 2024Article
- Effects of Deep-Brain Stimulation on Speech: Perceptual and Acoustic Data.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Lexicality-Modulated Influence of Auditory Cortex on Subthalamic Nucleus During Motor Planning for Speech.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis.Frontiers in neurology · 2023Article
- Human subthalamic nucleus neurons differentially encode speech and limb movement.Frontiers in human neuroscience · 2023Article
- Manipulation of vocal communication and anxiety through pharmacologic modulation of norepinephrine in the Pink1-/- rat model of Parkinson disease.Behavioural brain research · 2022Article
- Patient-Related Factors Influencing Caregiver Burden in Parkinson's Disease Patients: Comparison of Effects Before and After Deep Brain Stimulation.Journal of Parkinson's disease · 2022Article
- Speech dysfunction, cognition, and Parkinson's disease.Progress in brain research · 2022Review
- Globus Pallidus Internus (GPi) Deep Brain Stimulation for Parkinson's Disease: Expert Review and Commentary.Neurology and therapy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) has been reported to be successful in relieving the core motor symptoms of Parkinson's disease (PD) and motor fluctuations in the more advanced stages of the disease. However, data on the effects of DBS on speech performance are inconsistent. While there are some series of patients documenting that speech function was relatively unaffected by DBS of the nucleus subthalamicus (STN), other investigators reported on improvements of distinct parameters of oral control and voice. Though, these ameliorations of single speech modalities were not always accompanied by an improvement of overall speech intelligibility. On the other hand, there are also indications for an induction of dysarthria as an adverse effect of STN-DBS occurring at least in some patients with PD. Since a deterioration of speech function has more often been observed under high stimulation amplitudes, this phenomenon has been ascribed to a spread of current-to-adjacent pathways which might also be the reason for the sporadic observation of an onset of dysarthria under DBS of other basal ganglia targets (e.g., globus pallidus internus/GPi or thalamus/Vim). The aim of this paper is to review and evaluate reports in the literature on the effects of DBS on speech function in PD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.