Trial reportPloS one2012
Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Use of peripheral electrical stimulation on healthy individual and patients after stroke and its effects on the somatosensory evoked potentials. A systematic review.Frontiers in neurology · 2022Pooled it
- Effects of repetitive peripheral magnetic stimulation on spasticity evaluated with modified Ashworth scale/Ashworth scale in patients with spastic paralysis: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Effect of Using TheraBracelet on Grasping versus Reaching in Poststroke Rehabilitation.OTJR : occupation, participation and health · 2023Trial
- Peripheral Somatosensory Entrainment Modulates the Cross-Frequency Coupling of Movement-Related Theta-Gamma Oscillations.Brain connectivity · 2022Trial
- Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke.Trials · 2022Trial
- TheraBracelet Stimulation During Task-Practice Therapy to Improve Upper Extremity Function After Stroke: A Pilot Randomized Controlled Study.Physical therapy · 2019Trial
- Trial
- Oral somatosensation shapes lingual muscle maps in macaque orofacial primary motor cortex.bioRxiv : the preprint server for biology · 2026Article
- Frequency-Following Responses for Objective Neurophysiological Monitoring in Pediatric Fetal Alcohol Spectrum Disorder: A Proof of Concept Case Study During Non-Invasive Neuromodulation.Children (Basel, Switzerland) · 2026Article
- Effects of Transcranial Direct Current Stimulation Combined with Peripheral Electrical Stimulation on Upper Limb Function Recovery in Stroke: A Systematic Review and Meta-Analysis.Brain sciences · 2026Review
- Corticomuscular coherence and its non-invasive modulation in stroke applications: a narrative review.Neuroimage. Reports · 2026Article
- Article
- Central and peripheral factors moderating pain effects on motor control and disability in chronic lumbosacral radicular pain.Journal of neuroengineering and rehabilitation · 2025Article
- Acute and Subacute Effects of Session with the EXOPULSE Mollii Suit in a Multiple Sclerosis Patient: A Case Report.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Association of Knee Pain Frequency and Severity with Quadriceps Strength but Not Rate of Decline Over Four Years.ACR open rheumatology · 2025Article
- [The research progress on the improvement effect of repeated peripheral magnetic stimulation on upper limb and lower limb spasm after stroke].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Article
- Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability.Frontiers in human neuroscience · 2025Article
- Improved motor imagery skills after repetitive passive somatosensory stimulation: a parallel-group, pre-registered study.Frontiers in neural circuits · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30-50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N(20)-P(25) component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P(14)-N(20) SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.