ArticlePloS one2012
The temporal structure of behaviour and sleep homeostasis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Bifurcations and Hyperchaos in Mathematical Models of Sleep.Bioengineering (Basel, Switzerland) · 2026Review
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- Vigilance state dissociation induced by 5-MeO-DMT in mice.Communications biology · 2026Article
- A Lightweight Neural Network Based on Memory and Transition Probability for Accurate Real-Time Sleep Stage Classification.Brain sciences · 2025Article
- Evaluation of the Digital Ventilated Cage® system for circadian phenotyping.Scientific reports · 2025Article
- The cyclic interaction between daytime behavior and the sleep behavior of laboratory dogs.Scientific reports · 2022Article
- Waking experience modulates sleep need in mice.BMC biology · 2021Article
- Neural and Homeostatic Regulation of REM Sleep.Frontiers in psychology · 2020Review
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- Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting.Frontiers in cellular neuroscience · 2019Article
- Cortical region-specific sleep homeostasis in mice: effects of time of day and waking experience.Sleep · 2018Article
- Mathematical modeling of sleep state dynamics in a rodent model of shift work.Neurobiology of sleep and circadian rhythms · 2018Article
- Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Adenosine AScientific reports · 2017Article
- Article
- Stereotypic wheel running decreases cortical activity in mice.Nature communications · 2016Article
- Sleep, recovery, and metaregulation: explaining the benefits of sleep.Nature and science of sleep · 2015Article
- The GABAergic parafacial zone is a medullary slow wave sleep-promoting center.Nature neuroscience · 2014Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The amount and architecture of vigilance states are governed by two distinct processes, which occur at different time scales. The first, a slow one, is related to a wake/sleep dependent homeostatic Process S, which occurs on a time scale of hours, and is reflected in the dynamics of NREM sleep EEG slow-wave activity. The second, a fast one, is manifested in a regular alternation of two sleep states--NREM and REM sleep, which occur, in rodents, on a time scale of ~5-10 minutes. Neither the mechanisms underlying the time constants of these two processes--the slow one and the fast one, nor their functional significance are understood. Notably, both processes are primarily apparent during sleep, while their potential manifestation during wakefulness is obscured by ongoing behaviour. Here, we find, in mice provided with running wheels, that the two sleep processes become clearly apparent also during waking at the level of behavior and brain activity. Specifically, the slow process was manifested in the total duration of waking periods starting from dark onset, while the fast process was apparent in a regular occurrence of running bouts during the waking periods. The dynamics of both processes were stable within individual animals, but showed large interindividual variability. Importantly, the two processes were not independent: the periodic structure of waking behaviour (fast process) appeared to be a strong predictor of the capacity to sustain continuous wakefulness (slow process). The data indicate that the temporal organization of vigilance states on both the fast and the slow time scales may arise from a common neurophysiologic mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.