ReviewExperimental diabetes research2012
Impact of maternal diabetes on epigenetic modifications leading to diseases in the offspring.
Review in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between maternal diabetes and the risk of attention deficit hyperactivity disorder in offspring: an updated systematic review and meta-analysis.European child & adolescent psychiatry · 2025Pooled it
- Maternal dietary components in the development of gestational diabetes mellitus: a systematic review of observational studies to timely promotion of health.Nutrition journal · 2023Pooled it
- Prenatal exposure to gestational diabetes mellitus increases developmental defects in the enamel of offspring.PloS one · 2019Trial
- GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Gestational Diabetes Mellitus Increases the Risk of Atopic Dermatitis in Children: A National Retrospective Study with Analysis by Treatment Modality.Dermatology and therapy · 2026Article
- Multi-omics atlas of ovarian cellular and molecular responses to diabetes.Molecular metabolism · 2026Article
- Inappropriate range of fasting plasma glucose may affect embryo euploidy negatively: a retrospective cohort study.BMC women's health · 2025Article
- Review
- Pregestational Prediabetes Induces Maternal Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation and Results in Adverse Foetal Outcomes.International journal of molecular sciences · 2024Article
- Challenges and pitfalls of youth-onset type 2 diabetes.World journal of diabetes · 2024Review
- Measurement of Calprotectin and PTH in the Amniotic Fluid of Early Second Trimester Pregnancies and Their Impact on Fetuses with Growth Disorders: Are Their Levels Related to Oxidative Stress?Journal of clinical medicine · 2024Article
- Less common forms of diabetes in young population.Pediatric endocrinology, diabetes, and metabolism · 2024Review
- Impaired Angiogenic Function of Fetal Endothelial Progenitor Cells viaInternational journal of molecular sciences · 2023Article
- Assessing Knowledge on Gestational Diabetes Mellitus and Child Health.Hawai'i journal of health & social welfare · 2023Article
- Detection and Quantification of Neurotrophin-3 (NT-3) and Nerve Growth Factor (NGF) Levels in Early Second Trimester Amniotic Fluid: Investigation into a Possible Correlation with Abnormal Fetal Growth Velocity Patterns.Journal of clinical medicine · 2023Article
- Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?Medicina (Kaunas, Lithuania) · 2023Article
- An exploratory study of maternal diabetes and offspring use of dental services-Northern Ireland national cohort study.BDJ open · 2023Article
- Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years).Journal of cachexia, sarcopenia and muscle · 2023Article
- Effects of gestational diabetes mellitus and assisted reproductive technology treatment on the risk of preterm singleton birth.Frontiers in nutrition · 2022Article
- Increased Fibroblast Growth Factor 21 (FGF21) Concentration in Early Second Trimester Amniotic Fluid and Its Association with Fetal Growth.Metabolites · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes, occurring during the hyperglycemic period of pregnancy in maternal life, is a pathologic state that increases the incidence of complications in both mother and fetus. Offspring thus exposed to an adverse fetal and early postnatal environment may manifest increased susceptibility to a number of chronic diseases later in life. Compelling evidence for the role of epigenetic transmission in these complications has come from comparison of siblings born before and after the development of maternal diabetes, exposure to this intrauterine diabetic environment being shown to cause alterations in fetal growth patterns which predispose these infants to developing overweight and obesity later in life. Diabetes of the offspring is also mainly the consequence of exposure to the diabetic intrauterine environment, in addition to genetic susceptibility. Since obesity and diabetes are known to increase the risk of cardiovascular disease, cardiovascular sequelae in the offspring of diabetic mothers are virtually inevitable. Research data also suggest that exposure to a diabetic intrauterine environment during pregnancy is associated with an increase in dyslipidemia, subclinical vascular inflammation, and endothelial dysfunction processes in the offspring, all of which are linked with development of cardiovascular disease later in life. The main underlying mechanisms involve persistent hyperglycemia hyperinsulinemia and leptin resistance.
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