ArticleFrontiers in psychiatry2012
Gray matter volumetric abnormalities associated with the onset of psychosis.
Article in Frontiers in psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning.Schizophrenia (Heidelberg, Germany) · 2026Article
- Brain structural correlates of schizotypal signs and subclinical schizophrenia nuclear symptoms in healthy individuals.Psychological medicine · 2022Article
- Cortical Volume Differences in Subjects at Risk for Psychosis Are Driven by Surface Area.Schizophrenia bulletin · 2020Article
- Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State.Schizophrenia bulletin · 2020Article
- Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis.Schizophrenia bulletin · 2016Article
- Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.Schizophrenia bulletin · 2015Article
- Does neuroanatomy account for superior temporal dysfunction in early psychosis? A multimodal MRI investigation.Journal of psychiatry & neuroscience : JPN · 2015Article
- Cerebellar networks in individuals at ultra high-risk of psychosis: impact on postural sway and symptom severity.Human brain mapping · 2014Article
- Orbitofrontal cortex volume and intrinsic religiosity in non-clinical psychosis.Psychiatry research · 2014Article
- Cerebellar Morphology and Procedural Learning Impairment in Neuroleptic-Naive Youth at Ultrahigh Risk of Psychosis.Clinical psychological science : a journal of the Association for Psychological Science · 2014Article
- A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework.Frontiers in human neuroscience · 2014Article
- Cortical thickness as a contributor to abnormal oscillations in schizophrenia?NeuroImage. Clinical · 2014Article
- Neuron-glia interaction as a possible glue to translate the mind-brain gap: a novel multi-dimensional approach toward psychology and psychiatry.Frontiers in psychiatry · 2013Review
- Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.Child and adolescent psychiatric clinics of North America · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with psychosis display structural brain abnormalities in multiple brain regions. The disorder is characterized by a putative prodromal period called ultra-high-risk (UHR) status, which precedes the onset of full-blown psychotic symptoms. Recent studies on psychosis have focused on this period. Neuroimaging studies of UHR individuals for psychosis have revealed that the structural brain changes observed during the established phases of the disorder are already evident prior to the onset of the illness. Moreover, certain brain regions show extremely dynamic changes during the transition to psychosis. These neurobiological features may be used as prognostic and predictive biomarkers for psychosis. With advances in neuroimaging techniques, neuroimaging studies focusing on gray matter abnormalities provide new insights into the pathophysiology of psychosis, as well as new treatment strategies. Some of these novel approaches involve antioxidants administration, because it is suggested that this treatment may delay the progression of UHR to a full-blown psychosis and prevent progressive structural changes. The present review includes an update on the most recent developments in early intervention strategies for psychosis and potential therapeutic treatments for schizophrenia. First, we provide the basic knowledge of the brain regions associated with structural abnormalities in individuals at UHR. Next, we discuss the feasibility on the use of magnetic resonance imaging (MRI)-biomarkers in clinical practice. Then, we describe potential etiopathological mechanisms underlying structural brain abnormalities in prodromal psychosis. Finally, we discuss the potentials and limitations related to neuroimaging studies in individuals at UHR.
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