ArticleFrontiers in physiology2012
Identification of displaced endometrial glands and embryonic duct remnants in female fetal reproductive tract: possible pathogenetic role in endometriotic and pelvic neoplastic processes.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Uterine Müllerianosis.Journal of clinical medicine · 2026Article
- Identification of Misplaced Endometrial Glands and Stroma in the Myometrium of Foetal Uteri Evocative of Developmental Adenomyosis.International journal of molecular sciences · 2026Article
- The Role of Adenogenesis Factors in the Pathogenesis of Endometriosis.International journal of molecular sciences · 2025Review
- Uncommon diagnostic aspects of adolescent endometriosis: case series with narrative review of the literature.Frontiers in reproductive health · 2025Article
- Endometriosis and Depression: A Double Agony for Women.Annals of neurosciences · 2023Review
- Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement.Biomedicines · 2023Review
- Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility.International journal of molecular sciences · 2022Review
- New Insights in Pathogenesis of Endometriosis.Frontiers in medicine · 2022Review
- The Role of Peritoneal Macrophages in Endometriosis.International journal of molecular sciences · 2021Review
- MUC1 and E-cadherin immunohistochemistry of endometrium cannot predict the outcome ofF1000Research · 2019Article
- Article
- Looking for an effective and non-invasive diagnostic test for endometriosis: where are we?Annals of translational medicine · 2018Article
- Molecular and Cellular Pathogenesis of Endometriosis.Current women's health reviews · 2018Review
- Future Directions in Endometriosis Research and Therapeutics.Current women's health reviews · 2018Article
- Endometriosis origin from primordial germ cells.Organogenesis · 2017Review
- Anxiety and depression in patients with endometriosis: impact and management challenges.International journal of women's health · 2017Review
- The influence of menstrual cycle and endometriosis on endometrial methylome.Clinical epigenetics · 2016Article
- Gynecology and Obstetrics has Entered Modern Times: Perspectives and Challenges.Frontiers in surgery · 2014Article
- Endometriosis: a new cellular and molecular genetic approach for understanding the pathogenesis and evolutivity.Frontiers in surgery · 2014Article
- Combined targeting of TCF7L1/2, PTEN, CDK6, and BCCIP by microRNA miR-29c-3p is associated with reduced invasion and proliferation of endometriotic cells.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent findings strongly promoted the hypothesis that common pelvic gynecological diseases including endometriosis and ovarian neoplasia may develop de novo from ectopic endometrial-like glands and/or embryonic epithelial remnants. To verify the frequency, the anatomical localization and the phenotype of misplaced endometrial tissue along the fetal female reproductive tract, histological and immunohistochemical analyses of uteri, fallopian tubes, and uterosacral ligaments were performed.
methodsReproductive organs were collected from seven female fetuses at autopsy, five of them from gestational ages between 18 and 26 weeks and two fetuses with gestational ages of 33 and 36 weeks deceased of placental anomalies. Serial sections from areas containing ectopic glands and embryonic duct residues were analyzed by histological and immunohistochemical procedures.
resultsNumerous ectopic endometrial glands and stroma were detected in the myometrium in two fetuses with low levels of expression of estrogen receptor-alpha (ER-α) and progesterone receptors (PR). The embryonic ducts were localized in the uterine broad and ovarian ligaments and under the fallopian tube serosa in six fetuses. Low levels of steroid receptors expression were found in the embryonic residues, whereas the carcino-embryonic antigen (CEA) and the tumor marker Ca 125 were not detected. The embryonic residues stromal component strongly expressed the CD 10 and vimentin proteins.
conclusionThe anatomical and the immunohistochemical features of the ectopic organoid structures identified in fetal female reproductive tract suggest that endometriotic as well as neoplastic disease in adult women may develop on the basis of misplaced endometrial glands and/or embryonic cell remnants.
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