Evidence map›Paper›PMID 23226956›Full record

ReviewDialogues in clinical neuroscience2012

Functional magnetic resonance imaging of autism spectrum disorders.

Gabriel S Dichter

Open access · diamondAbstract readReview
In one paragraph

Review in Dialogues in clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 211 citations in OpenAlex.

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  9. Individual differences shape conceptual representation in the brain.bioRxiv : the preprint server for biology · 2025
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gabriel S DichterDepartments of Psychiatry and Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. dichter@med.unc.edu
University of North Carolina at Chapel Hill · US

Funding

RESTRICTED REPETITIVE BEHAVIOR IN AUTISMR01MH073402 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BODFISH, JAMES WILLIAM, DICHTER, GABRIEL S · 2004 to 2015
$2.9M
Functional Neuroimaging of Psychopharmacologic Intervention for AutismK23MH081285 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S · 2008 to 2012
$794k
NIMH NIH HHS K23 MH081285NIMH NIH HHS R01 MH073402
6 · The paper itself

Abstract

This review presents an overview of functional magnetic resonance imaging findings in autism spectrum disorders (ASDS), although there is considerable heterogeneity with respect to results across studies, common themes have emerged, including: (i) hypoactivation in nodes of the "social brain" during social processing tasks, including regions within the prefrontal cortex, the posterior superior temporal sulcus, the amygdala, and the fusiform gyrus; (ii) aberrant frontostriatal activation during cognitive control tasks relevant to restricted and repetitive behaviors and interests, including regions within the dorsal prefrontal cortex and the basal ganglia; (iii) differential lateralization and activation of language processing and production regions during communication tasks; (iv) anomalous mesolimbic responses to social and nonsocial rewards; (v) task-based long-range functional hypoconnectivity and short-range hyper-connectivity; and (vi) decreased anterior-posterior functional connectivity during resting states. These findings provide mechanistic accounts of ASD pathophysiology and suggest directions for future research aimed at elucidating etiologic models and developing rationally derived and targeted treatments.

Indexed as

Magnetic Resonance ImagingAdolescentBrainChildChild Development Disorders, PervasiveCognition DisordersHumansImage Processing, Computer-AssistedLanguage Development DisordersOxygenRewardSocial BehaviorTheory of MindOxygenautism spectrum disordercognitive controlconnectivityfMRIfunctional magnetic resonance imaginglanguagerepetitive behaviorreward

Identifiers

PMID23226956
PMCPMC3513685
OpenAlexW1496968292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.