ReviewDialogues in clinical neuroscience2012
Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders.
Review in Dialogues in clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endosomal system genetics and autism spectrum disorders: A literature review.Neuroscience and biobehavioral reviews · 2016Pooled it
- Decoding the genetic landscape of autism: A comprehensive review.World journal of clinical pediatrics · 2024Article
- Oligodendrocytes Death Induced Sensorimotor and Cognitive Deficit in N-nitro-L-arginine methyl Rat Model of Pre-eclampsia.Neurochemical research · 2020Article
- Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence.Toxicology reports · 2019Article
- Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex.Journal of neurodevelopmental disorders · 2018Article
- Spatiotemporal Proteomic Profiling of Human Cerebral Development.Molecular & cellular proteomics : MCP · 2017Article
- Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity.Frontiers in cellular neuroscience · 2017Review
- Developmental and Functional Brain Impairment in Offspring from Preeclampsia-Like Rats.Molecular neurobiology · 2016Article
- Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia.Frontiers in cellular neuroscience · 2015Article
- The Role of Epigenetic Change in Autism Spectrum Disorders.Frontiers in neurology · 2015Review
- Fusion of white and gray matter geometry: a framework for investigating brain development.Medical image analysis · 2014Article
- Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.Human molecular genetics · 2014Article
- An inside job: how endosomal Na(+)/H(+) exchangers link to autism and neurological disease.Frontiers in cellular neuroscience · 2014Review
- Orchestration of neurodevelopmental programs by RBFOX1: implications for autism spectrum disorder.International review of neurobiology · 2013Review
- Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells.Journal of neurogeneticsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii) pre-mRNA splicing; (iii) protein localization, translation, and turnover; (iv) synaptic transmission; (v) cell signaling; (vi) the functions of cytoskeletal and scaffolding proteins; and (vii) the function of neuronal cell adhesion molecules. While the molecular mechanisms appear broad, they may converge on only one of a few steps during neurodevelopment that perturbs the structure, function, and/or plasticity of neuronal circuitry. While there are many genetic mutations involved, novel treatments may need to target only one of few developmental mechanisms.
Indexed as
Identifiers
23226950PMC3513679What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.