Evidence map›Paper›PMID 23226938›Full record

ArticleJournal of biomedicine & biotechnology2012

Ultrastructural evidence of exosome secretion by progenitor cells in adult mouse myocardium and adult human cardiospheres.

Lucio Barile, Mihaela Gherghiceanu, Laurentiu M Popescu, Tiziano Moccetti, Giuseppe Vassalli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 71 citations in OpenAlex.

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  13. New Insights into the Role of Exosomes in the Heart After Myocardial Infarction.Journal of cardiovascular translational research · 2019
    Review
  14. Article
  15. Review
  16. Exosomes in the Regulation of Vascular Endothelial Cell Regeneration.Frontiers in cell and developmental biology · 2019
    Review
  17. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lucio BarileMolecular Cardiology Laboratory, Fondazione Cardiocentro Ticino, Via Tesserete, 6900 Lugano, Switzerland.
Mihaela Gherghiceanu
Laurentiu M Popescu
Tiziano Moccetti
Giuseppe Vassalli
Epatocentro Ticino · CHInstitutul National Victor Babes · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The demonstration of beneficial effects of cell therapy despite the persistence of only few transplanted cells in vivo suggests secreted factors may be the active component of this treatment. This so-called paracrine hypothesis is supported by observations that culture media conditioned by progenitor cells contain growth factors that mediate proangiogenic and cytoprotective effects. Cardiac progenitor cells in semi-suspension culture form spherical clusters (cardiospheres) that deliver paracrine signals to neighboring cells. A key component of paracrine secretion is exosomes, membrane vesicles that are stored intracellularly in endosomal compartments and are secreted when these structures fuse with the cell plasma membrane. Exosomes have been identified as the active component of proangiogenic effects of bone marrow CD34⁺ stem cells in mice and the regenerative effects of embryonic mesenchymal stem cells in infarcted hearts in pigs and mice. Here, we provide electron microscopic evidence of exosome secretion by progenitor cells in mouse myocardium and human cardiospheres. Exosomes are emerging as an attractive vector of paracrine signals delivered by progenitor cells. They can be stored as an "off-the-shelf" product. As such, exosomes have the potential for circumventing many of the limitations of viable cells for therapeutic applications in regenerative medicine.

Indexed as

AnimalsCell-Derived MicroparticlesClinical Trials as TopicExosomesFlow CytometryHumansMiceMyocardial IschemiaMyocardiumParacrine CommunicationSpheroids, CellularStem CellsStem Cell TransplantationTransplantation, Autologous

Identifiers

PMID23226938
PMCPMC3511851
OpenAlexW2035138695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.