ArticleMediators of inflammation2012
Changes in the monocytic subsets CD14(dim)CD16(+) and CD14(++)CD16(-) in chronic systolic heart failure patients.
Article in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02144480 (Efficacy of Early Short-term Training on Thrombogenesis in Patients Following Coronary Bypass Surgery), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Early Short-term Training on Thrombogenesis in Patients Following Coronary Bypass Surgery
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Association Between Monocyte Subsets and Cardiometabolic Disorders/Cardiovascular Disease: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Monocyte heterogeneity in cardiovascular disease.Cardiovascular research · 2023Article
- Differences in the Profile of Circulating Immune Cell Subsets in Males with Type 2 Cardiorenal Syndrome versus CKD Patients without Established Cardiovascular Disease.Biomedicines · 2023Article
- Altered compositions of monocyte, T lymphocyte and NK cell subsets in heart failure of adult congenital heart disease.International journal of cardiology. Congenital heart disease · 2022Article
- Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients.Biology · 2022Review
- Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 - An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives.Journal of inflammation research · 2022Review
- Emerging role of interleukin-13 in cardiovascular diseases: A ray of hope.Journal of cellular and molecular medicine · 2021Review
- Platelet Activity and Its Correlation with Inflammation and Cell Count Readings in Chronic Heart Failure Patients with Reduced Ejection Fraction.Medicina (Kaunas, Lithuania) · 2021Article
- Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection.AIDS research and human retroviruses · 2019Article
- Role of Monocytes in Heart Failure and Atrial Fibrillation.Journal of the American Heart Association · 2018Review
- ERBB signaling attenuates proinflammatory activation of nonclassical monocytes.American journal of physiology. Heart and circulatory physiology · 2017Article
- The Role of Inflammation in Cardiovascular Outcome.Current atherosclerosis reports · 2017Review
- Non classical Monocytes Levels, Increased by Subcutaneous Fat-Secretome, Are Associated with Less Rehospitalization after Heart Failure Admission.Journal of cardiovascular translational research · 2017Article
- Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice.BMB reports · 2017Article
- Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode.Journal of clinical laboratory analysis · 2016Observational
- Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure.World journal of cardiology · 2016Article
- Monocyte Subsets and Inflammatory Cytokines in Acute Decompensated Heart Failure.Journal of cardiac failure · 2016Article
- Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).Journal of immunotherapy applications · 2014Article
- Cardiopulmonary exercise capacity and preoperative markers of inflammation.Mediators of inflammation · 2014Article
- Acute exercise-induced response of monocyte subtypes in chronic heart and renal failure.Mediators of inflammation · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different monocytic subsets are important in inflammation and tissue remodelling, but although heart failure (HF) is associated with local and systemic inflammation, their roles in HF are yet unknown. We recruited 59 chronic systolic HF patients (aged 58 ± 13 years, 45 males and 14 females) and 29 age-matched controls with no pervious heart disease. Compared to the controls, we found no change in the distribution of the CD14(+)CD16(+) monocytic subset, whereas the classical CD14(++)CD16(-) subset was decreased by 11% (P < 0.001), and the nonclassical CD14(dim)CD16(+) subset was expanded by 4% (P < 0.001) in HF patients and was inversely associated with severe HF (P = 0.015), as assessed by increased end-diastolic dimension (EDD). Compared to the control group, serum TNFα, IL-1β, IL-10, and IL-13 levels were significantly elevated in the HF patients. Specifically, IL-13 levels were positively correlated to the CD1CD14(dim)CD16(+) monocytic subset (r = 0.277, P = 0.017), and intracellular staining of IL-13 demonstrated that some of these monocytes produce the cytokine in HF patients, but not in the controls. We suggest that the inverse association between EDD values and the expansion of CD14(dim)CD16(+) monocytes that can produce IL-13 could be explained as a measure to counterbalance adverse remodelling, which is a central process in HF.
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