Evidence map›Paper›PMID 23226922›Full record

ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2012

The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids.

Shuanhu Gao, Qiaoling Wang, Gelin Wang, Brett Lomenick, Jie Liu, Chih-Wei Fan, Lih-Wen Deng, Jing Huang, Lawrence Lum, Chuo Chen

Abstract read
In one paragraph

Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The Journal of organic chemistry · 2020
    Article
  3. Natural products as inspiration for the development of new synthetic methods.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuanhu GaoDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Qiaoling Wang
Gelin Wang
Brett Lomenick
Jie Liu
Chih-Wei Fan
Lih-Wen Deng
Jing Huang
Lawrence Lum
Chuo Chen

Funding

Structure guided discovery of small molecule antagonists of Smac (DIABLO)/XIPAP01CA095471 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MCKNIGHT, STEVEN L · 2002 to 2011
$34.1M
Asymmetric Synthesis of Biologically Active Marine Natural ProductsR01GM079554 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, CHUO · 2007 to 2016
$2.9M
Identifying molecular targets and biological signatures of CAM natural productsR01AT006889 · NCCIH · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, CHUO, HUANG, JING · 2011 to 2015
$2.2M
Hedgehog Signal Transduction Across the Cell MembraneR01GM076398 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LUM, LAWRENCE · 2006 to 2010
$1.6M
NCCIH NIH HHS R01 AT006889NCI NIH HHS P01 CA095471NIGMS NIH HHS R01 GM076398NIGMS NIH HHS R01 GM079554
6 · The paper itself

Abstract

Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

Identifiers

PMID23226922
PMCPMC3515072

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.