ArticleEvolutionary biology2012
The Developmental Basis of Quantitative Craniofacial Variation in Humans and Mice.
Article in Evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Shared genetic basis and structure of syndromic and normal facial variation.American journal of human genetics · 2026Article
- Gene expression dynamics of human and mouse craniofacial development at the single-cell level.Nature communications · 2026Article
- A Novel Approach to Study Cranial Shape in Children with Normal and Sagittal Synostosis: An Application of Geometric Morphometrics.Neurologia medico-chirurgica · 2025Article
- Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk.bioRxiv : the preprint server for biology · 2025Article
- Embryonic and early postnatal cranial bone volume and tissue mineral density values for C57BL/6J laboratory mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Numerical abnormalities of permanent dentition - a case report.Medicine and pharmacy reports · 2022Article
- Article
- The Skull's Girder: A Brief Review of the Cranial Base.Journal of developmental biology · 2021Review
- Article
- Anatomical similarity between the Sost-knockout mouse and sclerosteosis in humans.Anatomical record (Hoboken, N.J. : 2007) · 2020Article
- Craniofacial skeletal response to encephalization: How do we know what we think we know?American journal of physical anthropology · 2019Article
- Facial shape manifestations of growth faltering in Tanzanian children.Journal of anatomy · 2018Article
- Body size and allometric variation in facial shape in children.American journal of physical anthropology · 2018Article
- Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face.Scientific reports · 2018Article
- Article
- Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice.Frontiers in physiology · 2017Article
- Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2016Article
- Cranio-facial remodeling in domestic dogs is associated with changes in larynx position.Journal of anatomy · 2016Article
- Multivariate Analysis of Genotype-Phenotype Association.Genetics · 2016Article
- Anatomical network analysis shows decoupling of modular lability and complexity in the evolution of the primate skull.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 5 countries.
Funding
Abstract
The human skull is a complex and highly integrated structure that has long held the fascination of anthropologists and evolutionary biologists. Recent studies of the genetics of craniofacial variation reveal a very complex and multifactorial picture. These findings contrast with older ideas that posit much simpler developmental bases for variation in cranial morphology such as the growth of the brain or the growth of the chondrocranium relative to the dermatocranium. Such processes have been shown to have major effects on cranial morphology in mice. It is not known, however, whether they are relevant to explaining normal phenotypic variation in humans. To answer this question, we obtained vectors of shape change from mutant mouse models in which the developmental basis for the craniofacial phenotype is known to varying degrees, and compared these to a homologous dataset constructed from human crania obtained from a single population with a known genealogy. Our results show that the shape vectors associated with perturbations to chondrocranial growth, brain growth, and body size in mice do largely correspond to axes of covariation in humans. This finding supports the view that the developmental basis for craniofacial variation funnels down to a relatively small number of key developmental processes that are similar across mice and humans. Understanding these processes and how they influence craniofacial shape provides fundamental insights into the developmental basis for evolutionary change in the human skull as well as the developmental-genetic basis for normal phenotypic variation in craniofacial form.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.