ArticleBulletin of the World Health Organization2012
Understanding the modes of transmission model of new HIV infection and its use in prevention planning.
Article in Bulletin of the World Health Organization, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Challenges in Elucidating HIV-1 Genetic Diversity in the Middle East and North Africa: A Review Based on a Systematic Search.Viruses · 2025Pooled it
- HIV epidemiology among female sex workers and their clients in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions.BMC medicine · 2019Pooled it
- The HIV Modes of Transmission model: a systematic review of its findings and adherence to guidelines.Journal of the International AIDS Society · 2014Pooled it
- A systematic review of heterosexual anal intercourse and its role in the transmission of HIV and other sexually transmitted infections in Papua New Guinea.BMC public health · 2013Pooled it
- A qualitative exploration to understand barriers and facilitators to daily oral PrEP uptake and sustained adherence among HIV-negative women planning for or with pregnancy in rural Southwestern Uganda.Journal of the International AIDS Society · 2022Trial
- Changing sex risk behaviors, gender norms, and relationship dynamics among couples in Cape Town, South Africa: Efficacy of an intervention on the dyad.Social science & medicine (1982) · 2018Trial
- Three decades of HIV epidemic dynamics in The Gambia: a comprehensive analysis of prevalence, incidence, and mortality trends, 1990-2024.AIDS research and therapy · 2026Article
- Factors associated with awareness of and willingness to use PrEP among stable, heterosexual HIV-serodifferent couples in seven African countries, 2019-2022.Journal of the International AIDS Society · 2025Article
- Challenges and Opportunities in Big Data Science to Address Health Inequities and Focus the HIV Response.Current HIV/AIDS reports · 2024Review
- High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study.PLoS medicine · 2023Article
- Structural, Personal and Socioenvironmental Determinants of HIV Transmission among Transgender Women in Indonesia.International journal of environmental research and public health · 2021Article
- Modelling immune deterioration, immune recovery and state-specific duration of HIV-infected women with viral load adjustment: using parametric multistate model.BMC public health · 2020Article
- HIV Modes of Transmission in Sudan in 2014.International journal of health policy and management · 2020Article
- Acceptability of oral HIV self-testing among female sex workers in Gaborone, Botswana.PloS one · 2020Article
- Article
- Contribution of high risk groups' unmet needs may be underestimated in epidemic models without risk turnover: A mechanistic modelling analysis.Infectious Disease Modelling · 2020Article
- Measuring Relationship Functioning in South African Couples: A Strategy for Improving HIV Prevention Efforts.Sexual and relationship therapy : journal of the British Association for Sexual and Relationship Therapy · 2020Article
- Healthcare providers' understanding of HIV serodiscordance in South Africa and Uganda: implications for HIV prevention in sub-Saharan Africa.African journal of AIDS research : AJAR · 2018Article
- Estimating the contribution of key populations towards the spread of HIV in Dakar, Senegal.Journal of the International AIDS Society · 2018Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modes of transmission model has been widely used to help decision-makers target measures for preventing human immunodeficiency virus (HIV) infection. The model estimates the number of new HIV infections that will be acquired over the ensuing year by individuals in identified risk groups in a given population using data on the size of the groups, the aggregate risk behaviour in each group, the current prevalence of HIV infection among the sexual or injecting drug partners of individuals in each group, and the probability of HIV transmission associated with different risk behaviours. The strength of the model is its simplicity, which enables data from a variety of sources to be synthesized, resulting in better characterization of HIV epidemics in some settings. However, concerns have been raised about the assumptions underlying the model structure, about limitations in the data available for deriving input parameters and about interpretation and communication of the model results. The aim of this review was to improve the use of the model by reassessing its paradigm, structure and data requirements. We identified key questions to be asked when conducting an analysis and when interpreting the model results and make recommendations for strengthening the model's application in the future.
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