Trial reportPloS one2012
Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and FMRI.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07160049 (Focused Ultrasound Stimulation of Peripheral Nerves in Limbs), which is not on this map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Focused Ultrasound Stimulation of Peripheral Nerves in Limbs
Who cites it
48 citing papers in PubMed, 101 citations in OpenAlex.
- Noninvasive Diagnostic Ultrasound-Guided Focused Ultrasound Enables Selective, Reversible Inhibition of Peripheral Nociceptive Fibers and Prevents Acute Pain.bioRxiv : the preprint server for biology · 2026Article
- Displacement-Guided Focused Ultrasound of the Median Nerve Modulates Somatosensory Evoked Potentials in Humans.IEEE transactions on bio-medical engineering · 2026Article
- Photoacoustic: A Versatile Nongenetic Method for High-Precision Neuromodulation.Accounts of chemical research · 2024Review
- Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system.Advanced drug delivery reviews · 2024Review
- Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice.Nature communications · 2024Article
- Therapeutic ultrasound: an innovative approach for targeting neurological disorders affecting the basal ganglia.Frontiers in neuroanatomy · 2024Review
- Somatosensory integration in robot-assisted motor restoration post-stroke.Frontiers in aging neuroscience · 2024Article
- Effects of focused ultrasound in a "clean" mouse model of ultrasonic neuromodulation.iScience · 2023Article
- Interdependence of Tissue Temperature, Cavitation, and Displacement Imaging During Focused Ultrasound Nerve Sonication.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Peripheral focused ultrasound stimulation and its applications: From therapeutics to human-computer interaction.Frontiers in neuroscience · 2023Review
- Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation.Micromachines · 2022Article
- Strategies for precision vagus neuromodulation.Bioelectronic medicine · 2022Review
- Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ultrasound does not activate but can inhibit in vivo mammalian nerves across a wide range of parameters.Scientific reports · 2022Article
- Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial.Frontiers in psychiatry · 2022Article
- Mechanics Of Ultrasonic Neuromodulation In A Mouse Subject.Extreme Mechanics Letters · 2022Article
- 32 Element Piezoelectric Micromachined Ultrasound Transducer (PMUT) Phased Array for Neuromodulation.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2022Article
- Design and Optimization of Ultrasound Phased Arrays for Large-Scale Ultrasound Neuromodulation.IEEE transactions on biomedical circuits and systems · 2021Article
- MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound.iScience · 2021Article
- Region-specific effects of ultrasound on individual neurons in the awake mammalian brain.iScience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral somatosensory circuits are known to respond to diverse stimulus modalities. The energy modalities capable of eliciting somatosensory responses traditionally belong to mechanical, thermal, electromagnetic, and photonic domains. Ultrasound (US) applied to the periphery has also been reported to evoke diverse somatosensations. These observations however have been based primarily on subjective reports and lack neurophysiological descriptions. To investigate the effects of peripherally applied US on human somatosensory brain circuit activity we recorded evoked potentials using electroencephalography and conducted functional magnetic resonance imaging of blood oxygen level-dependent (BOLD) responses to fingertip stimulation with pulsed US. We found a pulsed US waveform designed to elicit a mild vibration sensation reliably triggered evoked potentials having distinct waveform morphologies including a large double-peaked vertex potential. Fingertip stimulation with this pulsed US waveform also led to the appearance of BOLD signals in brain regions responsible for somatosensory discrimination including the primary somatosensory cortex and parietal operculum, as well as brain regions involved in hierarchical somatosensory processing, such as the insula, anterior middle cingulate cortex, and supramarginal gyrus. By changing the energy profile of the pulsed US stimulus waveform we observed pulsed US can differentially activate somatosensory circuits and alter subjective reports that are concomitant with changes in evoked potential morphology and BOLD response patterns. Based on these observations we conclude pulsed US can functionally stimulate different somatosensory fibers and receptors, which may permit new approaches to the study and diagnosis of peripheral nerve injury, dysfunction, and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.