ArticlePloS one2012
Adverse drug reactions causing admission to a paediatric hospital.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- The epidemiology of drug-related hospital admissions in paediatrics - a systematic review.Archives of public health = Archives belges de sante publique · 2024Pooled it
- Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.The pharmacogenomics journal · 2020Pooled it
- Potential Direct Costs of Adverse Drug Events and Possible Cost Savings Achievable by their Prevention in Tuscany, Italy: A Model-Based Analysis.Drug safety · 2019Pooled it
- Mortality among patients due to adverse drug reactions that lead to hospitalization: a meta-analysis.European journal of clinical pharmacology · 2018Pooled it
- Hospitalizations due to preventable adverse reactions-a systematic review.European journal of clinical pharmacology · 2017Pooled it
- Comparative epidemiology of hospital-acquired adverse drug reactions in adults and children and their impact on cost and hospital stay--a systematic review.European journal of clinical pharmacology · 2013Pooled it
- A Complex Intervention to Prevent Medication-Related Hospital Admissions.Deutsches Arzteblatt international · 2023Trial
- A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality.The International journal of pharmacy practice · 2015Trial
- [Recording medication errors in Germany-a workshop report].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Article
- Lymphocyte transformation test in pediatric drug hypersensitivity: case series report from a tertiary care hospital.Frontiers in immunology · 2026Article
- Risk factors for drug hypersensitivity reactions in children.Italian journal of pediatrics · 2024Review
- Major Drug-Drug Interaction Exposure Among Medicaid-Insured Children in the Outpatient Setting.Pediatrics · 2024Article
- Medication errors and associated factors among pediatric inpatients in public hospitals of gamo zone, southern Ethiopia.Heliyon · 2023Article
- Adverse Drug Reactions in Children: Comparison of Reports Collected in a Pharmacovigilance Project Versus Spontaneously Collected ADR Reports.Paediatric drugs · 2023Article
- Adverse drug events and contributing factors among pediatric cancer patients at Jimma University medical center, Southwest Ethiopia.BMC pediatrics · 2023Observational
- Causality, Severity, and Avoidability of Adverse Drug Reactions in Hospitalized Children: A Prospective Cohort Study.Cureus · 2023Article
- Physicians' perspectives on adverse drug reactions in pediatric routine care: a survey.World journal of pediatrics : WJP · 2022Article
- Implementing a specialist paediatric clinical pharmacology service in a UK children's hospital.British journal of clinical pharmacology · 2022Article
- Pediatric pharmacogenomics: challenges and opportunities: on behalf of the Sanford Children's Genomic Medicine Consortium.The pharmacogenomics journal · 2021Review
- Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
OBJECTIVE(S): To obtain reliable information about the incidence of adverse drug reactions, and identify potential areas where intervention may reduce the burden of ill-health.
designProspective observational study.
settingA large tertiary children's hospital providing general and specialty care in the UK.
participantsAll acute paediatric admissions over a one year period. MAIN EXPOSURE: Any medication taken in the two weeks prior to admission. OUTCOME MEASURES: Occurrence of adverse drug reaction.
results240/8345 admissions in 178/6821 patients admitted acutely to a paediatric hospital were thought to be related to an adverse drug reaction, giving an estimated incidence of 2.9% (95% CI 2.5, 3.3), with the reaction directly causing, or contributing to the cause, of admission in 97.1% of cases. No deaths were attributable to an adverse drug reaction. 22.1% (95% CI 17%, 28%) of the reactions were either definitely or possibly avoidable. Prescriptions originating in the community accounted for 44/249 (17.7%) of adverse drug reactions, the remainder originating from hospital. 120/249 (48.2%) reactions resulted from treatment for malignancies. The drugs most commonly implicated in causing admissions were cytotoxic agents, corticosteroids, non-steroidal anti-inflammatory drugs, vaccines and immunosuppressants. The most common reactions were neutropenia, immunosuppression and thrombocytopenia.
conclusionsAdverse drug reactions in children are an important public health problem. Most of those serious enough to require hospital admission are due to hospital-based prescribing, of which just over a fifth may be avoidable. Strategies to reduce the burden of ill-health from adverse drug reactions causing admission are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.